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Estramustine Phosphate Sodium

Posted by admin on June 24th, 2011 No Comments

C23H30ClNNaO6P • Estramustine phosphate sodium, a complex of 17 ?-estradiol and nornitrogen mustard, is an antimicrotubule antineoplastic agent. Uses • Prostate Cancer Estramustine phosphate sodium is used for the palliative treatment of metastatic and/or progressive prostate cancer. The drug, alone or in combination with other antineoplastic agents, currently is considered by many clinicians to be an alternative to conventional measures (e.g., orchiectomy, hormonal therapy) and generally is used in the treatment of hormone-refractory prostate cancer. Safety and efficacy of estramustine have been evaluated in controlled and uncontrolled studies in patients with advanced metastatic prostate cancer refractory to conventional measures (e.g., hormonal therapy) as well as in those with previously untreated disease. Most studies were conducted before the realization that administration of estramustine with milk or calcium-containing products substantially impairs absorption of the drug; therefore, overall clinical efficacy (i.e., objective response) of estramustine may have been underestimated. Read more [...]

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Bicalutamide

Posted by admin on June 24th, 2011 No Comments

C18H14F4N2O4S • Bicalutamide, a nonsteroidal antiandrogen, is an antineoplastic agent. Uses • Prostate Cancer Bicalutamide is used in combination with a gonadotropin-releasing hormone (GnRH) luteinizing hormone-releasing hormone analog (e.g., goserelin or leuprolide acetate) for the palliative treatment of metastatic (stage D2) prostate cancer. In a double-blind, multicenter, randomized study in 813 patients with previously untreated advanced prostate cancer, similar survival rate, time to progression, and quality-of-life measurements were reported for bicalutamide (50 mg daily) and flutamide (250 mg 3 times daily) combined with a GnRH analog (goserelin acetate implant or leuprolide acetate depot). For additional information on combined antiandrogenic and GnRH analog therapy. Prostate specific antigen (PSA) concentrations should be determined periodically during bicalutamide therapy to monitor therapeutic response, including successful remission or possible progression of cancer. If PSA concentrations increase substantially and consistently during bicalutamide therapy, the possibility Read more [...]

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Abarelix

Posted by admin on June 24th, 2011 No Comments

C72H95ClN14O14 • Abarelix, a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone [LHRH], gonadorelin), is a GnRH antagonist that is used as an antineoplastic agent. Uses • Prostate Cancer Abarelix is used for the palliative treatment of advanced symptomatic prostate cancer when GnRH agonist therapy is not appropriate, orchiectomy is unacceptable to the patient, and one or more of the following risk factors and/or clinical manifestations are present: risk of neurologic compromise secondary to metastases, ureteral or bladder outlet obstruction secondary to local encroachment or metastatic disease, or severe bone pain from skeletal metastases that persists despite opiate analgesia. Safety and efficacy of abarelix were established in an open-label, multicenter, uncontrolled, single-arm study in 81 men with advanced symptomatic prostate cancer who were at risk for clinical exacerbation (flare) if treated with a GnRH agonist. Seventy-two of these patients received abarelix 100 mg by IM injection on days 1, 15, and 29 and then every Read more [...]

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LEUPROLIDE

Posted by admin on December 25th, 2010 No Comments

LEUPROLIDE (LOO-pro-lied) Other Names for this Medication: Lupron ®, Lupron Depot ®, Eligard ® (Brand Names) Appearance Leuprolide Injection: Cloudy solution for injection into a muscle or deep under the skin. Why this Medication is Used Leuprolide may be used for the treatment of prostate cancer. It may also be used for the treatment of cancer of the cervix, uterus, or breast How do you take this Medication Leupron Depot® is injected once a month or once every 3-4 months by your doctor or nurse. It is injected into a muscle. Leupron® monthly injection and Eligard® are injected subcutaneously (deep under the skin). Precautions • Lupron preparations may be stored at room temperature, in a cool dry place. Protect from light. Eligard® should be kept refrigerated between 2-8°C • Keep all medications and syringes out of the reach of children. • Be sure to visit your doctor every time for a repeat injection. Take your syringe with you. • Check with your doctor if you are planning to have children - Leuprolide may prevent conception or pregnancy. • If side effects Read more [...]

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Estramustine Sodium Phosphate

Posted by admin on November 12th, 2010 No Comments

Drug Nomenclature Synonyms: Estramustina, fosfato sódico de; NSC-89199 (estramustine phosphate); Ro-21-8837/001; Ro-22-2296/000 (estramustine) BAN: Estramustine Sodium Phosphate [BANM] USAN: Estramustine Phosphate Sodium INN: Estramustine Sodium Phosphate [rINNM (en)] INN: Fosfato sódico de estramustina [rINNM (es)] INN: Estramustine, Phosphate Sodique de [rINNM (fr)] INN: Natrii Estramustini Phosphas [rINNM (la)] INN: Натрия Естрамустина Фосфат [rINNM (ru)] Chemical name: Estra-1,3,5(10)-triene-3,17β-diol 3-[bis(2-chloroethyl)carbamate] 17-(disodium phosphate); Disodium 3-[bis(2-chloroethyl)-carbamoyloxy]estra-1,3,5(10)-trien-17β-yl orthophosphate Molecular formula: C23H30Cl2NNa2O6P =564.3 CAS: 2998-57-4 (estramustine); 4891-15-0 (estramustine phosphate); 52205-73-9 (estramustine sodium phosphate) ATC code: L01XX11 Pharmacopoeias. In British. British Pharmacopoeia 2008 (Estramustine Sodium Phosphate). A white or almost white powder. Freely soluble in water and in methyl alcohol; very slightly soluble in dehydrated alcohol and in chloroform. Read more [...]

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Docetaxel

Posted by admin on November 8th, 2010 No Comments

(British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Docetaxel; Docetaxol; Docetaxolum; Dosetaksoli; NSC-628503; RP-56976 BAN: Docetaxel USAN: Docetaxel INN: Docetaxel [rINN (en)] INN: Docetaxel [rINN (es)] INN: Docétaxel [rINN (fr)] INN: Docetaxelum [rINN (la)] INN: Доцетаксел [rINN (ru)] Chemical name: (2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β-20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate; tert-Butyl {(1S,2S)-2-[(2S,5R,7S,10R,13S)-4-acetoxy-2-benzoyloxy-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-13-yloxycarbonyl]-2-hydroxy-1-phenylethyl}carbamate Molecular formula: C43H53NO14 =807.9 CAS: 114977-28-5 (anhydrous docetaxel); 148408-66-6 (docetaxel trihydrate) ATC code: L01CD02 Read code: y08Xn Adverse Effects, Treatment, and Precautions As for Paclitaxel. Neutropenia, anaemia and skin reactions are common with docetaxel and may be severe. Fluid retention, resulting in oedema, Read more [...]

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Mitomycin

Posted by admin on November 3rd, 2010 No Comments

(British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Mitomicina; Mitomicinas; Mitomicinum; Mitomycin; Mitomycin C; Mitomycine C; Mitomycinum; Mitomysiini; NSC-26980 BAN: Mitomycin USAN: Mitomycin INN: Mitomycin [rINN (en)] INN: Mitomicina [rINN (es)] INN: Mitomycine [rINN (fr)] INN: Mitomycinum [rINN (la)] INN: Митомицин [rINN (ru)] Chemical name: 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-hydroxymethyl-8a-methoxy-5-methylazirino[2´,3´:3,4]pyrrolo[1,2-a]indole-4,7-dione carbamate; (1S,2S,9S,9aR)-7-Amino-2,3,5,8,9,9a-hexahydro-9a-methoxy-6-methyl-5,8-dioxo-1,2-epimino-1-H-pyrrolo[1,2-a]indol-9-ylmethyl carbamate Molecular formula: C15H18N4O5 =334.3 CAS: 50-07-7 ATC code: L01DC03 Read code: y02kT Description. Mitomycin is an antineoplastic antibiotic produced by the growth of Streptomyces caespitosus. Pharmacopoeias. In China, Europe, Japan, and US. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Mitomycin). A substance produced Read more [...]

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CIMETIDINE

Posted by admin on September 15th, 2010 No Comments

Indications benign gastric and duodenal ulceration, stomal ulcer, reflux oesophagitis, Zollinger-Ellison syndrome, other conditions where gastric acid reduction is beneficial Cautions see notes above; also hepatic impairment; interactions: histamine H2-antagonists and notes above Side-effects see notes above; also alopecia; very rarely tachycardia, galactorrhoea, interstitial nephritis Dose • 400 mg twice daily (with breakfast and at night) or 800 mg at night (benign gastric and duodenal ulceration) for at least 4 weeks (6 weeks in gastric ulceration, 8 weeks in NSAID-associated ulceration); when necessary the dose may be increased to 400 mg 4 times daily; INFANT under 1 year 20 mg/kg daily in divided doses has been used; CHILD 1-12 years, 25-30 mg/kg daily in divided doses; max. 400 mg 4 times daily Maintenance, 400 mg at night or 400 mg morning and night • Reflux oesophagitis, 400 mg 4 times daily for 4-8 weeks • Prophylaxis of stress ulceration, 200-400 mg every 4-6 hours • Gastric acid reduction (prophylaxis of acid aspiration; do not use syrup), obstetrics 400 mg Read more [...]

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FLUTAMIDE

Posted by admin on September 13th, 2010 No Comments

Indications advanced prostate cancer, see also notes above Cautions cardiac disease (oedema reported); hepatic impairment, also liver function tests, monthly for first 4 months, periodically thereafter and at the first sign or symptom of liver disorder (e.g. pruritus, dark urine, persistent anorexia, jaundice, abdominal pain, unexplained influenza-like symptoms); avoid excessive alcohol consumption Side-effects gynaecomastia (sometimes with galactorrhoea); nausea, vomiting, diarrhoea, increased appetite, insomnia, tiredness; other side-effects reported include decreased libido, reduced sperm count, gastric and chest pain, hypertension, headache, dizziness, oedema, blurred vision, thirst, rash, pruritus, haemolytic anaemia, systemic lupus erythematosus-like syndrome, and lymphoedema; hepatic injury (with transaminase abnormalities, cholestatic jaundice, hepatic necrosis, hepatic encephalopathy and occasional fatality) reported Dose • 250 mg 3 times daily (see also notes above) Flutamide (Non-proprietary) Tablets, flutamide 250 mg. Net price 84-tab pack = £21.66 Read more [...]

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Silodosin

Posted by admin on September 11th, 2010 No Comments

Drug Nomenclature Date of monograph revision: 14-Jun-2006; 28-Jun-2006 Synonyms: KMD-3213 INN: Silodosin [rINN (en)] INN: Silodosina [rINN (es)] INN: Silodosine [rINN (fr)] INN: Silodosinum [rINN (la)] INN: Сильодозин [rINN (ru)] Chemical name: (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide Molecular formula: C25H32F3N3O4 =495.5 CAS: 160970-54-7 Profile Silodosin is an alpha1-adrenoceptor blocker that is reported to be selective for the alpha1A-adrenoceptor subtype. It is used orally in benign prostatic hyperplasia to relieve symptoms of urinary obstruction. Proprietary Preparations Japan: Urief USA: Rapaflo Read more [...]

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