Benign Prostatic Hyperplasia – Prostate Cancer – Prostatitis

Archive for the ‘Prostatitis’ Category

Prostatitis: Advanced Therapy

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Prostatitis is one of the most perplexing disease entities with which the practicing urologist must contend. Also, the treatment of this disease is the least gratifying in that the patients often are labeled as "crazy" and have a poor response. In many ways, there are some significant similarities with interstitial cystitis, and perhaps some of the patients with complaints of prostatitis actually have interstitial cystitis, as has been suggested. Indeed, many of the symptoms and physical findings are similar and are outlined in Table 71-1. As in the case of interstitial cystitis, prostatitis has also been difficult to study, being a disease that lacked a formal and specific definition. Therefore, the National Institute for Diabetes, Digestive, and Kidney Diseases (NIDDKD) convened a consensus group to define prostatitis, expressly for the purpose of describing the different prostatitis syndromes in such a way that they could be investigated, and ultimately treated, in a more efficacious fashion. These new definitions, while not being radically different from the old criteria, serve the purpose of Read more [...]

Antibiotics

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Most urologists will treat prostatitis empirically with a course of antibiotics prior to receiving the results of any bacteriologic studies that are performed. Furthermore, most would continue the antibiotic for a full course (2 to 12 weeks), irrespective of the culture results. The only change, typically, would be considered if the antibiogram indicated that a particular organism was resistant to the antibiotic employed. The time course for treatment is highly variable. Most authors and research indicate that a period of 30 days is adequate but literature exists to support as long as 3 to 6 months of therapy. A number of antibiotics have been touted as the most appropriate for the treatment of classic chronic bacterial prostatitis or category II; these drugs should be used in category IIIA as well. Carbenicillin indanyl sodium (Geocillin-Roche) was probably the first antibiotic to have a specific indication for the treatment of prostatitis. It has an excellent spectrum of activity but it is cumbersome for patients as it is dosed four times a day. The tetracyclines as a group have an appropriately Read more [...]

Other Medications

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Many of the drugs that have been used in this disease have anti-inflammatory properties. Nonsteroidal anti-inflammatory agents are some of the most common agents used anecdotally These agents block prostaglandin synthesis and are able to reduce not only the inflammatory component but also the pain associated with prostatitis. Since pain is the primary manifestation of category IIIA prostatitis, these agents are highly likely to be efficacious. These medications also have a strong antispasmodic effect on smooth muscle. This would reduce the voiding pain and also presumably ameliorate the voiding dysfunction that is evident in this group of patients. These agents have been used extensively in the treatment of ureteral colic for the same reasons, and they have been shown to have this antispasmodic effect on the ureter. Another type of anti-inflammatory agent that has been used in abacterial prostatitis is the free-radical scavenger, allopurinol. It is the most widely used agent in this class. The mechanism of action involves the reduction of urate in the urine and prostatic secretions. The theory Read more [...]

Prostatitis: Factors InfluencingPrognosis

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Prostatitis is a poorly understood syndrome. This lack of understanding may adversely affect outcomes in patients with all forms of prostatitis. To improve on the prognosis of prostatitis, the clinician requires an excellent understanding of its epidemiology, evaluation, etiology, pathophysiology, and therapy. The goal of this chapter is to illustrate some common misconceptions concerning prostatitis and provide an up-to-date review of prostatitis syndromes, with special emphasis on factors affecting prognosis. The term prostatitis implies prostatic inflammation. Prostatitis, however, represents a number of disorders related to symptoms and/or signs referable to the lower urinary tract. Acute bacterial prostatitis, chronic bacterial prostatitis, nonbacterial prostatitis, and prostatodynia — or pelviperineal pain syndrome — represent the four categories of prostatitis. There is currently an emphasis on standardizing and reclassifying the various forms of the disorder to enhance physician understanding. The incidence of nonbacterial forms of the disease predominate — approximately 60% in Read more [...]

Evaluation

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The classic categorization of prostatitis into four main groups evolved in the 1960s and 1970s and has remained the standard. Patients don't always fit neatly into one category or another, however, and guidelines for treating such patients do not exist. What should be done, for instance, with the patient whose prostatic fluid culture is positive for an atypical organism or with the asymptomatic patient with leukocytes in their prostatic fluid? What treatment type would most likely benefit the patient with perineal pain but no voiding symptoms? The National Institutes of Health Consensus Conference on Prostatitis has devised a new prostatitis classification system to help solve these types of problems. Category I and II refer to acute and chronic bacterial prostatitis. Category III refers to chronic pelvic pain syndrome in the presence of negative prostatic fluid cultures. Category IIIA identifies patients with significant inflammation in the prostatic fluid, that is nonbacterial prostatitis, and category IIIB identifies patients without significant prostatic fluid inflammation, that is, prostatodynia. Read more [...]

Localization

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The localization method is the most accurate and efficient method of distinguishing between urethral, bladder, and prostate sources of inflammation or infection. The localization technique was initially described by Meares and Stamey et al. in 1968 and has become the standard for a thorough and methodic evaluation of prostatitis syndromes. Surprisingly, few primary care physicians and only about 50% of urologists perform localization evaluations on patients. In fact, one study revealed that only 33 to 45% of urologists even cultured urine or prostatic fluid as part of their evaluation. Physicians cite several reasons for not performing this basic and important diagnostic measure: it is cumbersome, perceived to have a low yield, and perceived to possess high false negative and false positive rates with low predictive value. Such a low percentage of physicians utilizing these basic diagnostic measures may impact adversely on treatment outcomes. Localization culture techniques have been described in detail elsewhere and will be briefly described here. The procedure involves analyzing aliquots of Read more [...]

Therapy and Prognosis

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Antimicrobial Therapy For an antimicrobial agent to be effective against prostatic infection, several properties of the agent must be met. First, the drug must achieve adequate bactericidal levels in both urine and prostate. Most commonly used agents today attain 50- to 100-fold greater urinary concentrations than serum concentration. Second, to enter the prostate under noninflammatory conditions, the agent should be lipid soluble and exist in the nonionized form. Once inside the prostate, the ideal agent should exist as a basic ion to trap itself within the prostate.''' The fluoroquinolones meet most of the above criteria and are the first agents of choice in treating bacterial prostatitis. Some have questioned whether an inflamed prostate represents a similar environment to the uninflamed prostate with respect to pharmacodynamics. To address this question, a group of investigators induced prostatitis in rats and then treated the animals with norfloxacin, followed by assays for intraprostatic norfloxacin levels. The authors found no difference in levels or efficacy of the antimicrobial and concluded Read more [...]

Prostatitis: Diagnosis

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Diagnosis and treatment of prostatitis requires diligence and persistence on the part of both the physician and the patient. Although diagnosis of acute bacterial prostatitis is easily made and its treatment straightforward, chronic bacterial prostatitis and other inflammatory prostatic syndromes are more difficult to define and differentiate. Diagnosis and documentation of specific infection is often elusive, despite careful evaluation. Clinical evaluation and diagnosis of prostatitis is variable. Family practice physicians and urologists do not routinely utilize a standard diagnosis protocol to evaluate patients with symptoms of prostatitis. Moon reviewed a questionnaire completed by primary care physicians and urologists diagnosing and treating prostatitis in Wisconsin. His study demonstrated that fewer than 50% of urologists and only 11 % of primary care providers evaluated expressed prostatic secretions to differentiate prostatic diseases. Similarly, few urologists or primary care physicians suggested nonantibacterial therapy to patients with prostatitis. While the nomenclature for prostatitis Read more [...]

Acute Bacterial Prostatitis

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The diagnosis of acute bacterial prostatitis is usually straightforward and readily apparent on physical examination. Patients are frequently febrile and toxic with severe rigors, back pain, perineal pain, dysuria, urgency, and frequency with associated mild to moderate obstructive urinary symptoms. As many as one-third of patients with acute bacterial prostatitis will present in acute urinary retention as a result of prostatic edema and enlargement secondary to acute inflammation of an already enlarged and partially obstructed urethra. Once a diagnosis is presumed by history, physical examination usually supports the diagnosis, with a rectal examination demonstrating a severely swollen, extremely tender prostate. Expression of prostatic secretions in acute bacterial prostatitis should not be performed because of the potential for systemic spread of prostatic infection. If prostatic fluid is available for microscopic examination, multiple polymorphonuclear leukocytes, both singularly and in clumps, are demonstrated. Urine culture as well as prostatic fluid culture will reveal the infectious pathogen, Read more [...]

Symptoms and Signs

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Most patients with nonacute inflammatory and infectious diseases of the prostate present with similar symptoms, including bladder inflammation with irritative voiding symptoms such as urinary frequency, urgency, and dysuria. Referred pain can occur to the low back, genitalia, supra-pubic area, and lower extremities; frequently perineal pain, scrotalgia, and postejaculatory discomfort occur alone or in combination in these patients. Obstructive symptoms are uncommon without coexistent prostatic hyperplasia. Obstructive symptoms may, however, occur in patients with associated bladder neck spasm and inflammatory prostatic conditions such as prostatodynia. Krieger and colleagues investigated the standardized evaluation of symptoms associated with chronic prostatitis. They compared a symptom index in 50 patients with prostatitis and 75 control patients. It was useful, reproducible, and helped in identifying symptoms. In their series, patients with prostatitis were more likely than control patients to complain of perineal, lower abdominal, testicular, penile, and postejaculatory pain as well as sexual Read more [...]