Doxazosin
Indications hypertension; benign prostatic hyperplasia
Cautions care with initial dose (postural hypotension); cataract surgery (risk of intra-operative floppy iris syndrome); susceptibility to heart failure; hepatic impairment; pregnancy; breast-feeding; interactions: alpha-blockers
Driving May affect performance of skilled tasks e.g. driving
Side-effects gastro-intestinal disturbances; oedema, hypotension, postural hypotension; dyspnoea, rhinitis, coughing; asthenia, fatigue, vertigo, dizziness, headache, paraesthesia, sleep disturbance, anxiety, depression; respiratory-tract infection, urinary-tract infection, influenza-like symptoms; back pain, myalgia; less commonly weight changes, flushing, syncope, tremor, agitation, micturition disturbance, impotence, epistaxis, arthralgia, tinnitus, hypersensitivity reactions (including pruritus, purpura, rash), alopecia; very rarely cholestasis, hepatitis, jaundice, bronchospasm, gynaecomastia, priapism, abnormal ejaculation, leucopenia, thrombocytopenia, blurred vision
Dose
• Hypertension, 1 mg daily, increased after 1-2 weeks to 2 mg once daily, and thereafter to 4 mg once daily, if necessary; max. 16 mg daily
Doxazosin (Non-proprietary)
Tablets, doxazosin (as mesilate) 1 mg, net price 28-tab pack = 93p; 2 mg, 28-tab pack = £1.00; 4 mg, 28-tab pack = £1.48. Counselling, initial dose, driving
Brands include Doxadura®
Cardura® (Pfizer)
Tablets, doxazosin (as mesilate) 1 mg, net price 28-tab pack = £10.56; 2 mg, 28-tab pack = £14.08. Counselling, initial dose, driving
Modified-release
Doxazosin (Non-proprietary)
Tablets, m/r, doxazosin (as mesilate) 4 mg, net price 28-tab pack = £6.33. Label: 25, counselling, initial dose, driving
Dose hypertension, benign prostatic hyperplasia, 4 mg once daily, increased to 8 mg once daily after 4 weeks if necessary
Brands include Doxadura® XL, Slocinx® XL
Cardura® XL (Pfizer)
Tablets, m/r, doxazosin (as mesilate) 4 mg, net price 28-tab pack = £5.70; 8 mg, 28-tab pack = £9.98. Label: 25, counselling, driving, initial dose
Dose hypertension, benign prostatic hyperplasia, 4 mg once daily, increased to 8 mg once daily after 4 weeks if necessary
Posted in: Drugs