Dutasteride

Posted by admin on August 25th, 2010 No Comments

Contents

Drug Approvals
Adverse Effects and Precautions
Pharmacokinetics
Uses and Administration
Proprietary Preparations

Drug Approvals

(British Approved Name, US Adopted Name, rINN)

Synonyms: Dutasterida; GG-745; GI-198745; GI-198745X

BAN: Dutasteride

USAN: Dutasteride

INN: Dutasteride [rINN (en)]

INN: Dutasterida [rINN (es)]

INN: Dutastéride [rINN (fr)]

INN: Dutasteridum [rINN (la)]

INN: Дутастерид [rINN (ru)]

Chemical name: α,α,α,α´,α´,α´-Hexafluoro-3-oxo-4-aza-5α-androst-1-ene-17β-carboxy-2´,5´-xylidide; 3-Oxo-2´,5´-bis(trifluoromethyl)-4-aza-5α-androst-1-ene-17β-carboxanilide

Molecular formula: C₂₇H₃₀F₆N₂O₂ =528.5

CAS: 164656-23-9

ATC code: G04CB02

Adverse Effects and Precautions

As for Finasteride.

Pharmacokinetics

Dutasteride is absorbed from the gastrointestinal tract, reaching a peak serum concentration in 1 to 3 hours, with a bioavailability of about 60%. It is highly bound to plasma proteins. Dutasteride is metabolised by the cytochrome P450 isoenzymes CYP3A4 and CYP3A5, and most of a dose is excreted as metabolites in the faeces. At steady state the elimination half-life is about 3 to 5 weeks.

Uses and Administration

Dutasteride, like finasteride, is an inhibitor of 5α-reductase. Unlike finasteride, it is claimed to inhibit both the type-1 and type-2 isoforms of the enzyme. Dutasteride is used in the treatment of benign prostatic hyperplasia it may reduce the incidence of acute urinary retention and the need for surgery. Dutasteride is given in doses of 500 micrograms daily by mouth. Response may be delayed and treatment for 6 months may be required to assess whether benefit has been achieved. Dutasteride is under investigation for the prevention of prostate cancer, and has been investigated in the treatment of alopecia.

Proprietary Preparations

Argentina: Avodart

Austria: Avodart Avolve Zyfetor

Belgium: Avodart

Canada: Avodart

Chile: Avodart

Czech Republic: Avodart

Denmark: Avodart

Finland: Avodart

France: Avodart

Germany: Avodart

Greece: Avodart Duagen

India: Duprost

Indonesia: Avodart

Ireland: Avodart

Israel: Avodart

Italy: Avodart

Malaysia: Avodart

Mexico: Avodart

The Netherlands: Avodart Duagen

Norway: Avodart

Philippines: Avodart

Poland: Avodart

Portugal: Avodart Avolve Duagen

Russia: Avodart

South Africa: Avodart

Singapure: Avodart

Spain: Avidart Duagen

Sweden: Avodart

Switzerland: Avodart

Turkey: Avodart

UK: Avodart

USA: Avodart

Chlorotrianisene Drug Approvals (British Approved Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish): Synonyms: Chlorotrianisenum; Clorotrianiseno; Klooritrianiseeni; Klortrianisen; NSC-10108; Tri-p-anisylchloroethylene BAN: Chlorotrianisene INN: Chlorotrianisene [rINN (en)] INN: Clorotrianiseno [rINN (es)] INN: Chlorotrianisène [rINN (fr)] INN: Chlorotrianisenum [rINN (la)] INN: Хлоротрианизен [rINN (ru)] Chemical name: Chlorotris(4-methoxyphenyl)ethylene Molecular formula: C23H21ClO3 ...
Silodosin Drug Nomenclature Date of monograph revision: 14-Jun-2006; 28-Jun-2006 Synonyms: KMD-3213 INN: Silodosin [rINN (en)] INN: Silodosina [rINN (es)] INN: Silodosine [rINN (fr)] INN: Silodosinum [rINN (la)] INN: Сильодозин [rINN (ru)] Chemical name: (-)-1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-2,3-dihydro-1H-indole-7-carboxamide Molecular formula: C25H32F3N3O4 =495.5 CAS: 160970-54-7 Profile Silodosin is an alpha1-adrenoceptor blocker that is reported to be selective for the alpha1A-adrenoceptor ...
Medrogestone Drug Approvals (British Approved Name, US Adopted Name, rINN) INNs in other languages (French, Latin, and Spanish): Synonyms: AY-62022; Medrogeston; Medrogestona; Medrogestoni; Medrogestonum; Metrogestone; NSC-123018; R-13-615 BAN: Medrogestone USAN: Medrogestone INN: Medrogestone [rINN (en)] INN: Medrogestona [rINN (es)] INN: Médrogestone [rINN (fr)] INN: Medrogestonum [rINN (la)] INN: Медрогестон [rINN (ru)] Chemical name: ...
Histrelin US Adopted Name, rINN Drug Nomenclature Synonyms: ORF-17070; RWJ-17070 USAN: Histrelin INN: Histrelin [rINN (en)] INN: Histrelina [rINN (es)] INN: Histréline [rINN (fr)] INN: Histrelinum [rINN (la)] INN: Гистрелин [rINN (ru)] Chemical name: 5-Oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-Nτ-benzyl-d-histidyl-l-leucyl-l-argininyl-N-ethyl-l-prolinamide Molecular formula: C66H86N18O12 =1323.5 CAS: 76712-82-8 ATC code: H01CA03 Histrelin Acetate INN: Histrelin Acetate [rINNM (en)] INN: Acetato de histrelina [rINNM (es)] INN: Histréline, ...
Nilutamide (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Nilutamid; Nilutamida; Nilutamidi; Nilutamidum; RU-23908 BAN: Nilutamide USAN: Nilutamide INN: Nilutamide [rINN (en)] INN: Nilutamida [rINN (es)] INN: Nilutamide [rINN (fr)] INN: Nilutamidum [rINN (la)] INN: Нилутамид [rINN (ru)] Chemical ...

Tags: Avodart, Dutasteride, Finasteride
Posted in: Drugs

Health and Prostate

Dutasteride

Drug Approvals

Adverse Effects and Precautions

Pharmacokinetics

Uses and Administration

Proprietary Preparations

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Symptoms and Treatment

Health and Prostate

Dutasteride

Drug Approvals

Adverse Effects and Precautions

Pharmacokinetics

Uses and Administration

Proprietary Preparations

Related Posts:

Leave a Reply

Symptoms and Treatment

Drugs. Meds