Effects of tissue localization of the androgen receptor on differentiation of the urogenital sinus

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Effects of tissue localization of the androgen receptor on differentiation of the urogenital sinus (UGS)

Epithelium and stroma from the urogenital sinuses of wild-type (androgen-receptor positive) or Tfm (androgen-receptor negative) mice were recombined and grafted under the renal capsule. Prostatic epithelium was obtained when wild-type or Tfm epithelium was recombined with wild-type stroma. Recombination of wild-type or Tfm epithelium with Tfm stroma resulted in development of a vaginal morphology.

Reproduced with permission from Cunha G R, Chung W K, Shannon J M, Reese B G. Stromal-epithelial interactions in sex differentiation. Biol Reprod 1980; 22.

Diagram of the human androgen receptor gene
[/caption] Black areas = trans-activation domains; P = proline directed phosphorylated Ser residues; HSP = heat shock protein; pKC = protein kinase C; pKA = protein kinase A; MAPK = mitogen-activated protein kinase; DNA-Dep ...
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Prostate cells in the absence of trophic factors A
Various prostate cells in the absence of trophic factors
Schematic diagram of the human androgen receptor gene

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Aspartate transport and citrate production in prostate luminal epithelial cells

[/caption] The low affinity L-aspartate transporter Na+-K+ ATPase and a citrate transporter are represented at the apical membrane. The high affinity L-aspartate transporter and glucose transporters are represented in the basal membrane. Reproduced ...

Diagnostic events for prostate cancer

Aspartate transport and citrate production in prostate luminal epithelial cells

Diagnostic events (in squares) in the sequence of screening and follow-up for prostate cancer. The size and darkness of the curved arrows indicate the current knowledge regarding diagnostic tools. Block arrows indicate the function of diagnostic ...

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