Benign Prostatic Hyperplasia – Prostate Cancer – Prostatitis

Histrelin

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US Adopted Name, rINN

Drug Nomenclature

Synonyms: ORF-17070; RWJ-17070
USAN: Histrelin
INN: Histrelin [rINN (en)]
INN: Histrelina [rINN (es)]
INN: Histréline [rINN (fr)]
INN: Histrelinum [rINN (la)]
INN: Гистрелин [rINN (ru)]
Chemical name: 5-Oxo-l-prolyl-l-histidyl-l-tryptophyl-l-seryl-l-tyrosyl-Nτ-benzyl-d-histidyl-l-leucyl-l-argininyl-N-ethyl-l-prolinamide
Molecular formula: C66H86N18O12 =1323.5
CAS: 76712-82-8
ATC code: H01CA03

Histrelin Acetate

INN: Histrelin Acetate [rINNM (en)]
INN: Acetato de histrelina [rINNM (es)]
INN: Histréline, Acétate d’ [rINNM (fr)]
INN: Histrelini Acetas [rINNM (la)]
INN: Гистрелина Ацетат [rINNM (ru)]
Molecular formula: C66H86N18O12,xC2H4O2,yH2O
CAS: 220810-26-4
ATC code: H01CA03

Adverse Effects and Precautions

As for Gonadorelin.

Uses and Administration

Histrelin is an analogue of gonadorelin with similar properties. A subcutaneous implant containing histrelin acetate 50 mg, and designed to release histrelin acetate 50 to 60 micrograms daily for 12 months, is used in the palliative treatment of advanced prostate cancer. Histrelin is used in the treatment of precocious puberty in children. It has also been investigated in disorders related to the menstrual cycle, and in the treatment of acute porphyr-ias.

Administration in children. For the suppression of gonadal sex hormone production in children with central precocious puberty, histrelin acetate has been given by subcutaneous inj ection in usual doses equivalent to histrelin 10 micrograms/kg daily. Alternatively, a subcutaneous implant containing histrelin acetate 50 mg and designed to release histrelin acetate 65 micrograms daily for 12 months may be used. The implant is not recommended for children under 2 years of age. References.

Proprietary Preparations

Malaysia: Vantas

USA: Supprelin; Vantas

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