MITOXANTRONE
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MITOXANTRONE (my-toe-ZAN-trone)
Other Names for this Medication (Brand Names): Mitox, Novantron, Novantrone
Appearance
Injection: A dark blue clear liquid for injection into the bloodstream.
Why this Medication is Used
This medication may be used alone, or in combination with other drugs, for the treatment of breast cancer, prostate cancer, acute myelogenous leukemia, liver cancer and Non-Hodgkin’s lymphoma.
How do you take this Medication
Injection: Mitoxantrone is injected into your vein by your chemotherapy nurse over a few minutes.
Precautions
• Your urine may be coloured blue-green for 1 or 2 days after your treatment. Your body eliminates the drug through both your urine and bowel movements. Wash your hands thoroughly after using the bathroom. In addition, the whites of your eyes may have a slight blue colour during treatment.
• Your doctor may ask you to drink plenty of clear fluids so that you will pass more urine.
• This medication may affect your heart after several treatments. Your doctor may order special heart tests, from time to time, to see how your heart is working.
• Tell your chemotherapy nurse immediately if you feel pain at injection site.
• This chemotherapy should not be used if you are pregnant or breast-feeding. It is important to discuss birth control with your doctor (Note: birth control pills alone are not recommended as the only birth control method). Birth control should also be used by female partners, if you are a male taking this medication
• It is important to tell your doctor if you have chickenpox (or have recently been exposed to someone who has had chickenpox), shingles, kidney disease or liver disease. Any of these conditions could affect therapy with this medication.
• Due to increased risk of infection check with your doctor before having any vaccinations. Check with your doctor, before any surgery or dental work.
• Do not take ASA without your doctor’s knowledge and consent.
> If a doctor has advised you to take ASA to prevent heart disease or stroke, please discuss this with your oncologist (cancer doctor) before starting treatment.
> Do not use ASA (aspirin, acetylsalicylic acid) for headache, fever, or occasional aches and pains; use acetaminophen (Tylenol) instead. Many non-prescription medications contain ASA; always ask your pharmacist’s advice when choosing a product.
For more information on this medication, please call your doctor, pharmacist or nurse.
| SIDE EFFECTS | PREVENTION | WHAT YOU SHOULD DO |
| MORE COMMON: | ||
| • Nausea and Vomiting
• Signs of infection: fever, chills, cough, sore throat, burning on urination. • Low white blood cells |
• Take prescribed medicine for nausea and vomiting. Continue drinking clear fluids.
• Limit your contact with people who are sick or have colds. Rest often. Wash your hands often. |
• If you vomit within 1 hour of taking antinausea medication you may take another tablet. If you are unable to take tablets, a suppository may be ordered. Get fresh air and rest. Phone your doctor if vomiting lasts more than 24 hours or nausea longer than 48 hours.
• Keep a thermometer at home. Recognize signs of infection. Phone your doctor or go to the emergency department right away if your temperature is over 38° C or 100° F. You may need antibiotics.. |
| LESS COMMON: | ||
| • Bruising or bleeding. Black, tar-like stools. Red spots on skin.
• Sore, red eyes. |
• Use sharp objects with care. Use a soft toothbrush. Tell your doctor before dental work is done.
• Avoid touching your eyes unnecessarily. |
• Phone your doctor immediately if bleeding or bruising is unusual or will not stop; or go to the Emergency Department.
• Avoid bright lights. Apply cool, wet face cloth to soothe. • Tell your doctor on your next visit. |
| RARE: | ||
| • Sores in the mouth or the lips
• Blue discolouring at place of injection • Pain or redness at place of injection • Skin rash. • Fast/irregular heartbeats; shortness of breath, trouble breathing; swelling of feet. • Hair thinning (from head and body). |
• Maintain good mouth hygiene. Brush teeth often with a soft toothbrush. Avoid hot, spicy and acidic foods. | • Check with your doctor or nurse as soon as you notice sores on mouth or lips.
• If painful, apply warm, wet face cloth to the area several times a day. • Tell your doctor or nurse • Tell your doctor as soon as possible. • Contact your doctor IMMEDIATELY! • Special heart tests may be ordered • A wig, hat, cap, scarf or hairpiece may be worn. • Your hair will regrow, once all of your treatments are over. |
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