Effects of tissue localization of the androgen receptor on differentiation of the urogenital sinus
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Effects of tissue localization of the androgen receptor on differentiation of the urogenital sinus (UGS)
Epithelium and stroma from the urogenital sinuses of wild-type (androgen-receptor positive) or Tfm (androgen-receptor negative) mice were recombined and grafted under the renal capsule. Prostatic epithelium was obtained when wild-type or Tfm epithelium was recombined with wild-type stroma. Recombination of wild-type or Tfm epithelium with Tfm stroma resulted in development of a vaginal morphology.
Reproduced with permission from Cunha G R, Chung W K, Shannon J M, Reese B G. Stromal-epithelial interactions in sex differentiation. Biol Reprod 1980; 22.
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