Diagnosis and Treatment of Prostatitis. Part 4
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| Antimicrobial Regimens for the Treatment of Acute and Chronic Bacterial Prostatitis | |||
| Drug class | Dose* and Route | Common Side Effects | Comments |
| Trimethoprim/ sulfamethoxazole |
160 mg TMP–800 mg SMX PO BID | Nausea, vomiting, diarrhea, photosensitivity | May be used for suppressive therapy as one single-strength tablet given once a day |
| Fluoroquinolones | |||
|
200 mg–400 mg PO BID | Nausea, vomiting, dizziness, insomnia, photosensitivity | Drug-drug interactions with theophylline, caffeine, warfarin and other drugs metabolized by the cytochrome p450 system. Drug-nutrient interactions with di– and trivalent cations (e.g., Mg, Al, Ca, Fe, Zn, and Cr) |
|
400 mg PO BID | ||
|
250 mg–500 mg PO BID | ||
| Aminopenicillins | |||
|
2 gm IV Q6h | Diarrhea, rash, hypersensitivity reactions | Contraindicated in patients with a history of penicillin anaphylaxis |
|
500 mg PO Q8h | ||
| Aminoglycosides | |||
|
1 mg/kg–2 mg/kg Q8h | Nephrotoxicity, vestibular and auditory toxicity | Serum concentrations need to be monitored for efficacy and toxicity |
|
1 mg/kg–2 mg/kg Q8h | ||
| * Doses of all agents must be adjusted based on age, weight, and hepatic and renal function. ABP = Acute bacterial prostatitis, CBP = Chronic bacterial prostatitis |
|||
U.S. Food and Drug Administration:
Active Ingredients: Sulfamethoxazole and Trimethoprim
Drug Name: Bactrim, Cotrim, Polytrim, Septra, Sulfamethoprim, Sulfatrim, Sulmeprim, Uroplus
Active Ingredients: Trimethoprim
Drug Name: Primsol, Proloprim, Trimethoprim, Trimpex
Active Ingredients: Sulfamethoxazole
Drug Name: Gantanol, Sulfamethoxazole, Urobak
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