Health and Prostate

Benign Prostatic Hyperplasia – Prostate Cancer – Prostatitis
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  • About 

    November 26, 2009, 12:09

    Prostate problems affect 30% of all men over 65 years of age. Most prostate problems can be divided into three categories: • Acute Prostatitis (infection) -…

  • BPH 

    May 25, 2010, 10:41

    Prostate enlargement, or BPH (benign prostatic hypertrophy), affects millions of men in the U. S., mostly those ages 50 and older. While it can be a serious…

  • Who Needs a Drug for BPH? 

    May 25, 2010, 10:45

    As we have already mentioned, many men with BPH don't have symptoms or their symptoms can be managed with lifestyle changes. About half of men of any age who…

  • Choosing a BPH Drug 

    May 25, 2010, 10:52

    As mentioned earlier, there are two main groups of drugs commonly used to treat BPH: alpha-blockers and 5-alpha-reductase inhibitors. (See Table 1 and Table 2…

  • Site Map 

    August 26, 2010, 07:59


Blog Posts

  • Category: Prostate Gland  (22)
    • Preserving Sexual Function in Men. Part 1 by: admin

      May 2, 2011, 11:12

      Preservation of sexual function has become an important consideration for our patients when contemplating therapeutic alternatives to their medical conditions…

    • Prostate-Specific Antigen (PSA) by: admin

      November 29, 2009, 10:17

      Prostate-Specific Antigen (PSA) is a serine protease normally produced by prostatic epithelial cells and present in high concentrations in prostatic secretions.…

    • Prostate specific antigen in urinary tract infection by: admin

      November 28, 2009, 15:42

      Prostate specific antigen (PSA) has a reported sensitivity for prostatic adenocarcinoma of up to 80%. However, it lacks specificity. The reported positive…

    • Early detection of prostate cancer. Part 4 by: admin

      November 28, 2009, 15:20

      Discussion Simplified technology has made it feasible for most laboratories in Canada to assay prostate-specific antigen. Very little systematic information…

    • Early detection of prostate cancer. Part 3 by: admin

      November 28, 2009, 15:20

      Screening Cost per prostate-specific antigen test including labour is about . Even in a less populous province, such as Newfoundland, with about 50000…

    • Early detection of prostate cancer. Part 2 by: admin

      November 28, 2009, 15:19

      Casefinding Casefinding for prostatic cancer is the responsibility of family physicians, and the two tests available to them are digital rectal examination…

    • Early detection of prostate cancer. Part 1 by: admin

      November 28, 2009, 15:18

      The media bombard physicians and patients alike with information on prostate-specific antigen (PSA) testing. Consequently, men in their middle and later years…

    • Preserving Sexual Function in Men. Part 2 by: admin

      November 28, 2009, 09:30

      Surgery that threatens function Until now we have discussed surgery to prevent future impairment of sexual function. Much urologic surgery also has the…

    • Treatments for Benign Prostatic Hyperplasia. Part 4 by: admin

      November 28, 2009, 06:59

      Transurethral prostatic resection Efficacy. Lepor and Rigaud critically examined the efficacy of transurethral prostatectomy in men with moderate symptoms…

    • Treatments for Benign Prostatic Hyperplasia. Part 3 by: admin

      November 28, 2009, 06:59

      Prostate balloon dilation Large diameter (75F to 90F), high-pressure (3 to 5 atm) balloons have been developed to dilate the prostate and bladder neck in a…

    • Treatments for Benign Prostatic Hyperplasia. Part 2 by: admin

      November 28, 2009, 06:58

      α-Adrenergic blockers It has been suggested that the dynamic component of obstruction, smooth muscle tone in bladder heck, prostate, urethra, and…

    • Treatments for Benign Prostatic Hyperplasia. Part 1 by: admin

      November 28, 2009, 06:57

      Benign Prostatic Hyperplasia (BPH) is the most common neoplasm affecting humans. More than 400 000 prostatectomies are performed annually in the United…

    • Moderate symptoms of benign prostatic hyperplasia. Part 2 by: admin

      November 26, 2009, 17:34

      Questions and Answers 1. Have similar studies been done comparing drug treatment to surgery or watchful waiting? No. It's very unlikely that anyone could…

    • Moderate symptoms of benign prostatic hyperplasia. Part 1 by: admin

      November 26, 2009, 17:33

      The urinary symptoms of benign prostatic hyperplasia (BPH) can range from very mild to severe enough to require prompt surgical treatment. Men with moderate…

    • Don't Forget Your PSA Test by: admin

      November 26, 2009, 16:58

      If you're a young man, you're probably not overly concerned about prostate cancer. If you are approaching the age of 50, you may be starting to wonder about…

    • Casodex and Zolvadex improve advanced prostate cancer by: admin

      November 26, 2009, 16:41

      Casodex (bicalutamide / Zeneca) is a safe and effective treatment for advanced prostate cancer when used in combination with LHRH-A therapy (medical castration)…

    • Benign Prostatic Hyperplasia (BPH) by: admin

      November 26, 2009, 15:53

      The prostate gland is part of the male reproductive system. It is located just below the bladder and surrounds the urethra, the small tube through which urine…

    • The Prostate. Part 5 by: admin

      November 26, 2009, 14:03

      Prostate Cancer: Medical or Surgical Castration? Some 30 to 40% of men over 50 years of age have prostate cancer. For advanced metastatic prostate cancer…

    • The Prostate. Part 4 by: admin

      November 26, 2009, 14:02

      Finasteride versus Terazosin for Benign Prostatic Hyperplasia Results from a large clinical trial comparing the 5-alpha-reductase inhibitor finasteride with…

    • The Prostate. Part 3 by: admin

      November 26, 2009, 14:00

      Treating Benign Prostatic Hyperplasia with Finasteride The androgens testosterone and dihydrotestosterone (DHT) control the development and function of the…

    • The Prostate. Part 2 by: admin

      November 26, 2009, 13:59

      Detecting Prostate Cancer: Prostate-Specific Antigen Assay If prostate cancer is diagnosed and treated during early stages, patients have a 5-year survival…

    • The Prostate. Part 1 by: admin

      November 26, 2009, 13:56

      Pathophysiology of the Prostate Gland: Benign Prostatic Hyperplasia and Cancer The prostate is a small, walnut-shaped gland that lies below the urinary…

  • Category: Prostate Cancer  (81)
    • Prostate Cancer: Management of Complications of the Disease and Its Therapy by: admin

      June 21, 2011, 09:53

      The prostate is the leading cancer site in American men, accounting for 29% of new cancer cases and a projected 184,500 new cases in 1998. Also in 1998, 39,200…

    • Osseous Metastases by: admin

      June 21, 2011, 09:50

      Persistent bone pain in the back or hip region is one of the most common presenting symptoms of metastatic disease. The imaging modality of choice in this…

    • Spinal Cord Compression and Other Complications of Osseous Metastases by: admin

      June 21, 2011, 09:50

      Complications of osseous metastases include spinal cord compression, seen ultimately in 10% of men with prostate cancer (which is second only to lung cancer as…

    • Management of Pain from Osseous Metastases by: admin

      June 21, 2011, 09:47

      Radiation therapy is used to manage symptomatic bone metastases that are unresponsive to androgen deprivation. For the patient with one or a few sites of…

    • Chemoprevention of Cancer of the Prostate by: admin

      June 21, 2011, 09:45

      With a dramatic increase in the number of prostate cancers detected as a result of prostate-specific antigen screening and the resulting public focus on the…

    • Opportunities for Chemoprevention by: admin

      June 21, 2011, 09:44

      Vitamin E The term "vitamin E" is used to refer to a group of naturally occurring substances that have vitamin E activity including a-, β-, δ-, and…

    • Anorectal Complications of Prostate Surgery by: admin

      June 21, 2011, 09:40

      Major iatrogenic injuries of the anorectum during prostate surgery are unusual occurrences. They are, however, challenging and troublesome clinical situations…

    • Repair of Rectal Injuries by: admin

      June 21, 2011, 09:39

      Rectal injuries noted at the time of prostate surgery may be repaired with primary closure without fecal diversion in most cases. Diversion is indicated in…

    • Fecal Incontinence by: admin

      June 21, 2011, 09:38

      Fecal incontinence is difficult to assess in an objective manner because there is no widely accepted scoring or grading system by which to compare patients. It…

    • Node-Positive Prostate Cancer by: admin

      June 21, 2011, 08:00

      Node-Positive Prostate Cancer: the Case for Observation There has been much progress made in the diagnosis and staging of prostate cancer in recent years. The…

    • Endocrine Therapy and Observation by: admin

      June 21, 2011, 07:59

      Outcome variables in treating node-positive prostate cancer have traditionally included local progression (bladder outlet obstruction, ureteral obstruction,…

    • Screening for Prostate Cancer by: admin

      June 21, 2011, 07:51

      Screening for Prostate Cancer: the Case for Screening The American Cancer Society estimates that there will be 179,300 new cases of prostate cancer diagnosed…

    • Screening by Digital Rectal Examination by: admin

      June 21, 2011, 07:50

      Before the widespread clinical use of prostate-specific antigen, digital rectal examination was the most common initial test for the diagnosis of prostate…

    • Prostate-specific antigen Derivatives by: admin

      June 21, 2011, 07:49

      The sensitivity of prostate-specific antigen has never been questioned. It is the test's lack of specificity (i.e., the number of false-positives that result…

    • The Status of Screening by: admin

      June 21, 2011, 07:47

      There are reports that support the notion that since the introduction of prostate-specific antigen in the late 1980s, prostate-specific antigen-based prostate…

    • Epidemiology of Prostate Cancer in Hispanic Americans by: admin

      June 21, 2011, 07:40

      Definition of Hispanics The United States Bureau of the Census established the term "Hispanic" in 1970 to identify people of Spanish origin. The Hispanic…

    • Pathologic Outcome by: admin

      June 21, 2011, 07:39

      In a retrospective review of 336 men (24 Hispanics, 33 African Americans, 279 non-Hispanic Caucasians) who did not receive neoadjuvant hormonal therapy and…

    • Hormonal Therapies by: admin

      May 6, 2011, 09:28

      Overview. Several hormonal therapies are in development for CaP. Baxter Oncology's D-63153 and teverelix (Ardana's Antaralix) are decapeptide luteinizing…

    • Epidermal Growth Factor Receptor Inhibitors by: admin

      May 6, 2011, 09:27

      Overview. A vast amount of R&D has been committed to the study of epidermal growth factor receptor (EGFR) inhibition. Although several EGFR inhibitors…

    • Antisense Therapies by: admin

      May 6, 2011, 09:26

      Overview. Despite its promise, no antisense therapy for the treatment of cancer has yet been approved. Genta (in collaboration with Sanofi-Aventis) and…

    • Angiogenesis Inhibitors by: admin

      May 6, 2011, 09:25

      Overview. Angiogenesis inhibition for the treatment of solid tumors has received a boost from the approval of bevacizumab (Genentech / Roche's Avastin) for…

    • Proteasome Inhibitors by: admin

      May 6, 2011, 09:23

      Overview. The proteasome is a novel target for cancer drugs, and clinical studies in myeloma have generated intense excitement in this field. Because the…

    • Immunoconjugates by: admin

      May 6, 2011, 09:23

      Overview. Immunoconjugation is a means of delivering cytotoxic molecules to tumor cells. The effector molecules are attached to monoclonal antibodies (MAbs),…

    • Onyvax-P by: admin

      May 6, 2011, 09:22

      Onyvax's Onyvax-P is a whole-cell allogeneic vaccine in Phase II development in the United Kingdom for CaP. The vaccine consists of three replication-deficient…

    • GVAX by: admin

      May 6, 2011, 09:21

      Cell Genesys's GVAX vaccine for CaP consists of tumor cells that have been irradiated and genetically modified to secrete GM-CSF, a hormone that plays a key…

    • Provenge.  by: admin

      May 6, 2011, 09:20

      Provenge (formerly APC-8015) is a dendritic cell-based vaccine in Phase III development by Dendreon. The company prepares the vaccine by isolating dendritic…

    • Vaccines by: admin

      May 6, 2011, 09:19

      Overview. The development of vaccines is one of the most active areas of CaP research. Each of the vaccines described in the following paragraphs has…

    • Atrasentan.  by: admin

      May 6, 2011, 09:19

      Atrasentan (Abbott Laboratories' Xinlay, formerly ABT-627) is an oral, small-molecule, selective ET-A-receptor antagonist that appears to slow the…

    • Endothelin-Receptor Antagonists by: admin

      May 6, 2011, 09:18

      Overview. Endothelin-receptor antagonists represent a new generation of oral, targeted, cytostatic agents. They have huge commercial potential if they can…

    • Satraplatin by: admin

      May 6, 2011, 09:17

      Satraplatin (GPC Biotech's JM-216) is a third-generation oral platinum agent. Satraplatin reentered Phase III development for second-line treatment of…

    • Patupilone by: admin

      May 6, 2011, 09:17

      Patupilone (Novartis' EPO-906), an intravenously administered formulation of epothilone B, is in Phase II trials for CaP in the United States. It is also in…

    • Ixabepilone by: admin

      May 6, 2011, 09:16

      Ixabepilone (Bristol-Myers Squibb's BMS-247550, formerly NSC-710428) is an epothilone tubulin inhibitor in Phase II development for CaP and Phase III for…

    • Cytotoxic Agents by: admin

      May 6, 2011, 09:15

      Overview. CaP has historically been perceived as chemotherapy-resistant, but the FDA's recent approval of docetaxel (Aventis' Taxotere) for hormone-refractory…

    • Irofulven by: admin

      May 6, 2011, 09:14

      Irofulven (hydroxymethylacylfulvene, MGI Pharma's MGI-114) is an acylfulvene in Phase II trials for CaP. MGI Pharma is investigating the agent's activity in…

    • Emerging Therapies by: admin

      May 6, 2011, 09:12

      Prostate cancer (CaP) R&D is an extremely active field; several diverse agents will likely be launched by the end of 2006, and more than 90 agents are in…

    • Nonpharmacological Approaches by: admin

      May 6, 2011, 09:11

      Watchful Waiting. Watchful waiting (no treatment other than observation with PSA testing) is a standard approach for men who choose to postpone or avoid…

    • Mitoxantrone / Prednisone by: admin

      May 6, 2011, 09:10

      Overview. Mitoxantrone (Serono / Wyeth Lederle's Novantrone, Baxter's Onkotrone) is marketed for the treatment of hormone-refractory metastatic CaP in…

    • Docetaxel / Estramustine by: admin

      May 6, 2011, 09:09

      Overview. Researchers have investigated estramustine in combination with many chemotherapy agents. For example, the combination of estramustine with…

    • Docetaxel / Prednisone by: admin

      May 6, 2011, 09:08

      Overview. In May 2004, the FDA approved the regimen of docetaxel (Sanofi-Aventis's Taxotere) plus prednisone (Merck's Decortin, generics) for the treatment…

    • Estramustine (Single Agent) by: admin

      May 6, 2011, 09:07

      Overview. Until recently, estramustine (Pfizer's Emcyt / Estracyt, Nihon Kayaku's Estracyt, generics) was one of two chemotherapeutic agents marketed for the…

    • Combined Androgen Blockade by: admin

      May 6, 2011, 09:05

      Overview. Combined androgen blockade (CAB)—sometimes called androgen -deprivation therapy—is the simultaneous administration of an LHRH analogue and an…

    • Steroidal Antiandrogens by: admin

      May 6, 2011, 09:04

      Overview. Chronic administration of steroidal androgens can suppress adrenocortical function (i.e., interfere with the body's ability to regulate endogenous…

    • Luteinizing Hormone-Releasing Hormone Antagonists by: admin

      May 6, 2011, 09:02

      Overview. LHRH antagonists are the most recent class of hormonal therapy to enter the CaP armamentarium. Mechanism Of Action. Compared with LHRH analogues…

    • Luteinizing Hormone-Releasing Hormone Analogues by: admin

      May 6, 2011, 09:01

      Overview. Luteinizing hormone-releasing hormone (LHRH) analogues are central to the treatment of all patients with hormone-sensitive CaP. LHRH analogues are…

    • Current Therapies by: admin

      May 6, 2011, 08:59

      The main treatment modalities for prostate cancer (CaP) include "watchful waiting"; local therapy (prostatectomy or radiotherapy, either external beam…

    • Etiology by: admin

      May 6, 2011, 08:58

      The precise etiology of CaP is unknown, although studies suggest that CaP occurs as a result of complex interactions between exposure to environmental toxins…

    • Pathophysiology by: admin

      May 6, 2011, 08:56

      Biology Of Prostate Cancer. The development and maintenance of the normal adult prostate are under the hormonal control of androgens acting through the…

    • Etiology and pathophysiology by: admin

      May 6, 2011, 08:53

      Typically, tumors of the prostate grow slowly. The vast majority arise in the subcapsular peripheral region of the posterior lobe—a region of the gland that…

    • Prostate Cancer Study Suggests No Treatment Is Acceptable for Some by: admin

      December 29, 2010, 18:16

      A study of hundreds of men with prostate cancer supports the idea that those over age 65 with slow-growing tumors may live as long without treatment as with…

    • Prostate Cancer, Dietary Fat Linked by: admin

      December 25, 2010, 18:13

      Study Finds That Limiting Intake of Red Meat Reduces Disease Risk Eating a lot of fat, especially from red meat, increases a man's risk of life-threate…

    • Prostate cancer: what men don't know by: admin

      December 21, 2010, 12:46

      When a tiny shadow turned up on Nancy Reagan's mammogram, nearly everyone understood that it raised the specter of breast cancer. A person on the street could…

    • Blood Test Backed for Prostate Cancer by: admin

      December 18, 2010, 18:11

      Detection Method Said to Offer Hope for Higher Cure Rate A simple, blood test is the best way to check for prostate cancer, the second biggest…

    • Blood Test Approved For Prostate Cancer by: admin

      December 15, 2010, 18:08

      FDA Stops Short of Recommending Procedure The Food and Drug Administration yesterday approved the first blood test for detecting prostate cancer. The…

    • Prostate Cancer Thrives on Ignorance, Fear by: admin

      December 12, 2010, 18:07

      The urgency of the matter was reiterated by health care professionals during a forum at George Washington University on Monday: Black men in the nation's…

    • Prostate Cancer Poses Tough Choices by: admin

      December 8, 2010, 18:04

      As he mulls possible treatments for his newly diagnosed prostate cancer, D.C. Mayor Marion Barry confronts his own version of a dilemma facing more than…

    • Prostate Cancer and Potency by: admin

      December 3, 2010, 17:58

      More and more men, at an earlier and earlier age, are going to be confronted with a decision on how to be treated for prostate cancer. The impression of…

    • Calcium and prostate cancer by: admin

      October 11, 2010, 17:06

      A diet rich in calcium may help reduce the risk of some types of colon cancer and is essential for strong bones. However, some scientists suggest that an…

    • Prostate Cancer Prevention by: admin

      September 25, 2010, 06:05

      While advanced metastatic prostate cancer has no cure at this time, prevention of this deadly disease is the best way to "cure" it now. There are two questions…

    • Vitamin D and Prostate Cancer by: admin

      September 20, 2010, 05:42

      Nutritional factors have been hypothesized to be critical in the development of numerous cancers, and this holds true for prostate cancer. On the basis of…

    • Development of New Vitamin D Analogs by: admin

      September 17, 2010, 05:38

      Development of New Vitamin D Analogs and Their Use in Combination Therapy for Prostate Cancer The beneficial effects of 1,25-VD against cancer cell…

    • Historic overview of hormone therapy for prostate cancer by: admin

      June 18, 2010, 09:48

      The response of prostate cancer to androgen ablation is among the most reproducible, durable, and profound of any systemic therapy for a solid tumor. The early…

    • Antioxidant vitamins and the development of prostate cancer by: admin

      January 28, 2010, 07:39

      A new report suggests that the antioxidant vitamins C and E appear to counteract some of the negative effects of male hormones (androgens) on prostate cells…

    • Surgical Removal of Testes and Flutamide by: admin

      January 27, 2010, 07:35

      Effect on Survival Rate of Metastatic Prostate Cancer Patients A recent report concludes that treatment with the drug flutamide following surgical removal…

    • Post-castration Drug Therapy in Prostate Cancer Patients by: admin

      January 26, 2010, 07:21

      A new study concludes that men treated with the drug flutamide after surgical castration for advanced metastatic prostate cancer have poorer qualities of life,…

    • Vitamin Supplement Reduces Prostate Cancer Incidence by: admin

      January 25, 2010, 07:12

      In the Journal of the National Cancer Institute (1998; 90: 440-6), researchers report that long-term supplementation with alpha-tocopherol reduced prostate…

    • New Radiation Therapy for Prostate Cancer by: admin

      January 23, 2010, 08:04

      Seller of cancer therapies becomes a patient with a success story Cancer has been a part of Don Mills' life for 17 years, but it was only in the last year…

    • The role of ketoconazole in advanced prostate cancer by: admin

      January 22, 2010, 05:49

      Ketoconazole - Nizoral, Extina, Xolegel, Kuric Prostate cancer is the most common malignancy in American males above age 55. The cause of prostate cancer is…

    • Prostate Cancer: The Pharmacist's Role by: admin

      January 18, 2010, 15:08

      Pharmacists have an important role in the treatment of patients with prostate cancer. Monitoring patients for adverse effects of drug therapy, drug/disease…

    • Prostate Cancer: Options in Moderate- and Late-Stage Cancer  by: admin

      January 17, 2010, 14:58

      External beam radiation therapy (EBRT) and interstitial implantation (brachytherapy) are the two types of radiation therapy (RT) currently available for…

    • Prostate Cancer: Options in Therapy for Early-Stage Cancer  by: admin

      January 16, 2010, 14:55

      The current treatments for organ-confined prostate cancer are watchful waiting, radical prostatectomy (RP), and radiation therapy (RT). Watchful Waiting:…

    • Prostate Cancer: Prevention by: admin

      January 15, 2010, 14:52

      At this time, there is not an approved chemoprevention agent for prostate cancer, though this is an active area of study. Finasteride is a 5a-reductase…

    • Prostate Cancer: Clinical Presentation by: admin

      January 14, 2010, 12:57

      Due to current recommendations for screening, most patients are asymptomatic at the time of diagnosis. Prostate cancer is often a slowly progressing disease.…

    • Prostate Cancer: Screening by: admin

      January 13, 2010, 12:49

      Controversy surrounds screening for prostate cancer with the main arguments being questionable cost-effectiveness and overdiagnosis when the disease can be…

    • Prostate Cancer: Risk Factors by: admin

      January 12, 2010, 12:40

      There are a variety of risk factors associated with prostate cancer (Table 1). Age, race, and genetics are the most likely risk indicators. Although rare…

    • Prostate Cancer: Introduction by: admin

      January 11, 2010, 12:26

      Prostate cancer is the second most common cancer in men. Pharmacists not only monitor drug side effects, interactions, and adherence but also prevent complicati…

    • Prostate Brachytherapy Becoming More Popular by: admin

      January 10, 2010, 12:01

      An old technique for treating prostate cancer is enjoying new popularity, thanks to advances in computer technology, says Dr. William J. Ellis of the University…

    • "Trojan Horse" For Prostate Cancer Treatment by: admin

      January 7, 2010, 11:43

      There may be a safe, effective, non-invasive gene therapy to treat early prostate cancer. Based on research from a Population Council scientist, the prospective…

    • Viadur: Treatment of Advanced Prostate Cancer by: admin

      January 5, 2010, 07:57

      Brand Name: Viadur Active Ingredient: leuprolide acetate implant Indication: Palliative treatment of advanced prostate cancer Company Name: ALZA Corporation …

    • Trelstar Depot: Treatment of Advanced Prostate Cancer by: admin

      January 4, 2010, 07:39

      Brand Name:  Trelstar Depot Active Ingredient: triptorelin pamoate Indication: Palliative treatment of advanced prostate cancer in patients in whom…

    • New findings on benign prostate hyperplasia and prostate cancer by: admin

      January 2, 2010, 10:09

      A recent study provides new insights into both prostate cancer and benign prostate hyperplasia (BPH). Researchers at New York's Memorial Sloan-Kettering Cancer…

    • Casodex and Zolvadex improve advanced prostate cancer by: admin

      November 26, 2009, 16:41

      Casodex (bicalutamide / Zeneca) is a safe and effective treatment for advanced prostate cancer when used in combination with LHRH-A therapy (medical castration)…

  • Category: Drugs  (57)
    • Triptorelin Pamoate by: admin

      June 24, 2011, 11:18

      C64H82N18O13 • Triptorelin pamoate, a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone,…

    • Nilutamide by: admin

      June 24, 2011, 11:15

      C12H10F3N3O4 • Nilutamide is a nonsteroidal antiandrogen. Uses • Prostate Cancer Nilutamide is used in combination with orchiectomy in the…

    • Mitoxantrone Hydrochloride by: admin

      June 24, 2011, 11:13

      C22H28N4O6•2HCl DHAD • Mitoxantrone hydrochloride, a synthetic anthracenedione, is an antineoplastic agent. Uses Mitoxantrone is used as a…

    • Leuprolide Acetate by: admin

      June 24, 2011, 11:09

      C59H84N16O12•C2H4O2 • Leuprolide acetate, a synthetic nonapeptide analog of naturally occurring porcine or ovine gonadotropin releasing hormone (GnRH,…

    • Leuprolide Acetate: Cautions by: admin

      June 24, 2011, 10:58

      Leuprolide generally is well tolerated and usual dosages (i.e., 1 mg daily) have been associated with fewer adverse systemic effects than usual dosages (i.e.,…

    • Leuprolide Acetate: Dosage and Administration by: admin

      June 24, 2011, 10:54

      • Reconstitution and Administration Leuprolide acetate suspension is administered IM, and leuprolide acetate injection is administered subcutaneously. The…

    • Leuprolide Acetate: Uses by: admin

      June 24, 2011, 10:53

      • Prostate Cancer Leuprolide acetate is used for the palliative treatment of advanced prostate cancer. The drug currently is considered alternative…

    • Goserelin Acetate by: admin

      June 24, 2011, 10:36

      C 59H 84N 18O 14 • Goserelin acetate, a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone,…

    • Goserelin Acetate: Dosage and Administration by: admin

      June 24, 2011, 10:31

      • General Goserelin acetate is administered as a biodegradable implant subcutaneously into the upper abdominal wall, under the supervision of a clinician.…

    • Flutamide by: admin

      June 24, 2011, 10:00

      C11H11F3N2O3 • Flutamide, a nonsteroidal antiandrogen, is an antineoplastic agent. Uses • Prostate Cancer Flutamide is used in combination with a…

    • Estramustine Phosphate Sodium by: admin

      June 24, 2011, 09:58

      C23H30ClNNaO6P • Estramustine phosphate sodium, a complex of 17 ?-estradiol and nornitrogen mustard, is an antimicrotubule antineoplastic agent. Uses •…

    • Bicalutamide by: admin

      June 24, 2011, 09:55

      C18H14F4N2O4S • Bicalutamide, a nonsteroidal antiandrogen, is an antineoplastic agent. Uses • Prostate Cancer Bicalutamide is used in combination…

    • Abarelix by: admin

      June 24, 2011, 09:42

      C72H95ClN14O14 • Abarelix, a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone , gonadorelin),…

    • LEUPROLIDE by: admin

      December 25, 2010, 18:14

      LEUPROLIDE (LOO-pro-lied) Other Names for this Medication: Lupron ®, Lupron Depot ®, Eligard ® (Brand Names) Appearance Leuprolide Injection: Cloudy…

    • Estramustine Sodium Phosphate by: admin

      November 12, 2010, 07:26

      Drug Nomenclature Synonyms: Estramustina, fosfato sódico de; NSC-89199 (estramustine phosphate); Ro-21-8837/001; Ro-22-2296/000 (estramustine) BAN:…

    • Docetaxel by: admin

      November 8, 2010, 07:18

      (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and…

    • Mitomycin by: admin

      November 3, 2010, 07:08

      (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and…

    • CIMETIDINE by: admin

      September 15, 2010, 07:59

      Indications benign gastric and duodenal ulceration, stomal ulcer, reflux oesophagitis, Zollinger-Ellison syndrome, other conditions where gastric acid…

    • FLUTAMIDE by: admin

      September 13, 2010, 07:51

      Indications advanced prostate cancer, see also notes above Cautions cardiac disease (oedema reported); hepatic impairment, also liver function tests,…

    • Silodosin by: admin

      September 11, 2010, 07:40

      Drug Nomenclature Date of monograph revision: 14-Jun-2006; 28-Jun-2006 Synonyms: KMD-3213 INN: Silodosin INN: Silodosina INN: Silodosine INN:…

    • Prazosin by: admin

      September 9, 2010, 07:30

      Indications hypertension; congestive heart failure; Raynaud's syndrome; benign prostatic hyperplasia Cautions first dose may cause collapse due to hypotensio…

    • Doxazosin by: admin

      September 7, 2010, 07:25

      Indications hypertension; benign prostatic hyperplasia Cautions care with initial dose (postural hypotension); cataract surgery (risk of intra-operative…

    • Terazosin by: admin

      September 5, 2010, 07:17

      Indications mild to moderate hypertension (see notes above); benign prostatic hyperplasia Cautions first dose may cause collapse due to hypotension (within…

    • Bicalutamide by: admin

      September 2, 2010, 13:59

      (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and…

    • Tamsulosin Hydrochloride by: admin

      August 28, 2010, 06:49

      Drug Approvals (British Approved Name Modified, US Adopted Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and…

    • Dutasteride by: admin

      August 25, 2010, 06:36

      Drug Approvals (British Approved Name, US Adopted Name, rINN) Synonyms: Dutasterida; GG-745; GI-198745; GI-198745X BAN: Dutasteride USAN: Dutasteride INN:…

    • Medrogestone by: admin

      August 22, 2010, 05:59

      Drug Approvals (British Approved Name, US Adopted Name, rINN) INNs in other languages (French, Latin, and Spanish): Synonyms: AY-62022; Medrogeston;…

    • Testolactone by: admin

      August 19, 2010, 05:53

      (British Approved Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms:…

    • Tamoxifen Citrate by: admin

      August 15, 2010, 05:37

      (British Approved Name Modified, US Adopted Name, rINNM) Drug Nomenclature INNs in main languages (French, Latin, Russian, and Spanish): Synonyms: ICI-46474;…

    • Fluorouracil by: admin

      August 12, 2010, 05:23

      (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and…

    • Progesterone by: admin

      August 9, 2010, 11:43

      (British Approved Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms:…

    • Megestrol Acetate by: admin

      August 5, 2010, 11:34

      Drug Approvals (BANM, US Adopted Name, rINNM) Synonyms: BDH-1298; Compound 5071; Megestrol, acetato de; Megestrol-acetát; Megestrolacetat; Megestroli…

    • Chlorotrianisene by: admin

      August 3, 2010, 11:29

      Drug Approvals (British Approved Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish): Synonyms: Chlorotria…

    • Flutamide by: admin

      July 20, 2010, 08:00

      (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and…

    • Aminoglutethimide by: admin

      July 20, 2010, 06:57

      (British Approved Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms:…

    • Nilutamide by: admin

      July 20, 2010, 06:47

      (British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and…

    • Histrelin by: admin

      July 19, 2010, 08:45

      US Adopted Name, rINN Drug Nomenclature Synonyms: ORF-17070; RWJ-17070 USAN: Histrelin INN: Histrelin INN: Histrelina INN: Histréline INN:…

    • Triptorelin by: admin

      July 17, 2010, 14:15

      Drug Approvals (British Approved Name, US Adopted Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish): Sy…

    • Finasteride by: admin

      June 11, 2010, 01:01

      Drug Approvals (British Approved Name, US Adopted Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish):…

    • Alfuzosin Hydrochloride by: admin

      June 8, 2010, 16:04

      Drug Approvals (British Approved Name Modified, US Adopted Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and…

    • DOCETAXEL by: admin

      June 5, 2010, 11:05

      DOCETAXEL (doe-seh-TAX-ell) Other Names for this Medication (Brand Name): Taxotere Appearance: Injection: Clear solution for injection, as an intravenous…

    • TAMSULOSIN by: admin

      May 18, 2010, 08:56

      TAMSULOSIN (tam-SOO-loe-sin) Other Names for this Medication (Brand names): Flomax, Harnal, Omnic, Pradif, Tamsolusin, Tamsulosina , Tamsulosine , Tamsulosin…

    • MITOXANTRONE by: admin

      May 15, 2010, 07:34

      MITOXANTRONE (my-toe-ZAN-trone) Other Names for this Medication (Brand Names): Mitox, Novantron, Novantrone Appearance Injection: A dark blue clear liquid…

    • GOSERELIN by: admin

      May 9, 2010, 05:52

      GOSERELIN (go-SARE-i-lin) Other Names for this Medication: Zoladex® (Brand Name) Appearance Injection: Prefilled syringe and needle for injection Why…

    • FLUTAMIDE by: admin

      May 6, 2010, 05:42

      FLUTAMIDE (FLUTE-am-eyed) Other Names for this Medication: Euflex®, Drogenil®, Eulexin ®, Apo-flutamide®, Novo-flutamide®, Pms-flutamide® (Brand…

    • ESTRAMUSTINE by: admin

      May 3, 2010, 05:30

      ESTRAMUSTINE (ess-tra-MUSS-teen) Other Names for this Medication: Emcyt, Estracit(Brand Names) Appearance White capsules containing 140mg Estramustine. …

    • CYPROTERONE Acetate by: admin

      April 30, 2010, 15:25

      CYPROTERONE Acetate (sigh-PRO-ter-own ASS-e-tate) Other Names for this Medication: Androcur, Cyprostat, Cyproteron, Procur, Cyprone, Cyprohexal,…

    • BUSERELIN DEPOT by: admin

      April 27, 2010, 15:11

      BUSERELIN DEPOT (byoo-SE-rel-in) Other Names for this Medication: Suprefact® Depot (Brand name) Appearance Injection: Pre-filled syringe and needle for…

    • BICALUTAMIDE by: admin

      April 24, 2010, 15:03

      BICALUTAMIDE (bye-cal-LOO-ta-mide) Other Names for this Medication Casodex, Cosudex, Calutide, Kalumid (Brand Names) Appearance White tablet containing…

    • ALFUZOSIN by: admin

      April 20, 2010, 14:24

      ALFUZOSIN (al-FOO-zoe-sin) Other Names for this Medication: US - Uroxatral, Canada - Xatral Appearance White and yellow 3 layered round (10 mg) tablets Wh…

    • Common questions about Proscar by: admin

      April 17, 2010, 12:33

      What is symptomatic benign prostatic hyperplasia (BPH)? In many men, after the age of 45, the prostate starts a process of enlargement called BPH. As the…

    • Can finasteride (Proscar) reverse the progress of BPH? by: admin

      April 9, 2010, 08:12

      Benign prostatic hyperplasia (BPH) refers to a complex of symptoms that can include difficult, painful or frequent urination, interrupted stream, hesitancy in…

    • Prostatonin: Herbal Product Eases Urinary Prostate Symptoms by: admin

      April 6, 2010, 08:06

      As men age, many begin to suffer annoying urinary problems — frequent trips to the bathroom, waking at night to urinate, inability to fully empty the…

    • Tamsulosin (Flomax) for Benign Prostatic Hyperplasia by: admin

      March 25, 2010, 07:19

      Generic Name Drug: Tamsulosin Hydrochloride Trade Name Drug: Flomax (Boehringer Ingelheim Pharmaceuticals, Inc.) Use: Treatment of signs and symptoms of…

    • Terazosin (Hytrin), finasteride (Proscar), or both in BPH by: admin

      March 21, 2010, 05:56

      Glossary Adrenergic: Relating to nerve cells of the autonomic nervous system. Alpha- and beta-adrenergic receptors receive chemical signals controlling…

    • Plenaxis (abarelix): Drug for Advanced Prostate Cancer by: admin

      March 19, 2010, 04:05

      The FDA has approved a New Drug Application (NDA) that permits marketing of Plenaxis (abarelix), a drug for advanced prostate cancer for patients who have no…

    • Plenaxis (Abarelix): drug for the treatment of advanced prostate cancer by: admin

      March 13, 2010, 01:36

      Trade Name Drug: Plenaxis Generic Name Drug: Abarelix Company: Praecis Pharmaceuticals Indication/Use: Prostate cancer Approval Date: Nov. 25, 2003 FDA…

  • Category: Prostate Specific Antigen  (4)
  • Category: Questions & Answers  (7)
  • Category: Prostatitis  (26)
    • Prostatitis: Advanced Therapy by: admin

      June 21, 2011, 11:00

      Prostatitis is one of the most perplexing disease entities with which the practicing urologist must contend. Also, the treatment of this disease is the least…

    • Antibiotics by: admin

      June 21, 2011, 10:59

      Most urologists will treat prostatitis empirically with a course of antibiotics prior to receiving the results of any bacteriologic studies that are performed.…

    • Other Medications by: admin

      June 21, 2011, 10:58

      Many of the drugs that have been used in this disease have anti-inflammatory properties. Nonsteroidal anti-inflammatory agents are some of the most common…

    • Prostatitis: Factors InfluencingPrognosis by: admin

      June 21, 2011, 10:57

      Prostatitis is a poorly understood syndrome. This lack of understanding may adversely affect outcomes in patients with all forms of prostatitis. To improve on…

    • Evaluation by: admin

      June 21, 2011, 10:56

      The classic categorization of prostatitis into four main groups evolved in the 1960s and 1970s and has remained the standard. Patients don't always fit neatly…

    • Localization by: admin

      June 21, 2011, 10:55

      The localization method is the most accurate and efficient method of distinguishing between urethral, bladder, and prostate sources of inflammation or…

    • Therapy and Prognosis by: admin

      June 21, 2011, 10:54

      Antimicrobial Therapy For an antimicrobial agent to be effective against prostatic infection, several properties of the agent must be met. First, the drug…

    • Prostatitis: Diagnosis by: admin

      June 21, 2011, 10:52

      Diagnosis and treatment of prostatitis requires diligence and persistence on the part of both the physician and the patient. Although diagnosis of acute…

    • Acute Bacterial Prostatitis by: admin

      June 21, 2011, 10:52

      The diagnosis of acute bacterial prostatitis is usually straightforward and readily apparent on physical examination. Patients are frequently febrile and toxic…

    • Symptoms and Signs by: admin

      June 21, 2011, 10:51

      Most patients with nonacute inflammatory and infectious diseases of the prostate present with similar symptoms, including bladder inflammation with irritative…

    • Radiographic Examination by: admin

      June 21, 2011, 10:50

      Radiographic examination of patients with chronic bacterial prostatitis and prostatitis inflammatory syndromes is usually unnecessary and findings are…

    • Chronic Bacterial Prostatitis in the Elderly by: admin

      May 5, 2011, 13:30

      Chronic bacterial prostatitis is now recognized as an important cause of relapses of urinary tract infection in elderly men. It is most commonly caused by E.…

    • Diagnosis and Treatment of Prostatitis. Part 5 by: admin

      May 4, 2011, 13:26

      Nonbacterial Prostatitis Nonbacterial prostatitis (NBP) is the most common type of prostatitis, and occurs eight times more frequently than bacterial…

    • Research and Treatments Ahead for Prostatitis by: admin

      January 8, 2010, 11:53

      Every year, men make over two million visits to the doctor because of prostatitis, a condition that causes chronic pelvic pain, urinary problems and often pain…

    • Trimethoprim-sulfamethoxazole in the treatment of chronic prostatitis. Part 3 by: admin

      December 6, 2009, 12:34

      Results Of the 40 patients who received trimethoprim-sulfamethoxazole for 6 weeks, 9 were classed as failures. These either had no response or relapsed…

    • Trimethoprim-sulfamethoxazole in the treatment of chronic prostatitis. Part 2 by: admin

      December 6, 2009, 12:33

      Treatment Antibiotic therapy with appropriate agents, even in well documented infections, rarely proved successful in the past because the diffusion of most…

    • Trimethoprim-sulfamethoxazole in the treatment of chronic prostatitis. Part 1 by: admin

      December 6, 2009, 12:31

      Chronic prostatitis is a common condition occurring in younger men which presents problems of diagnosis and treatment. In some patients a bacterial population…

    • Diagnosis and Treatment of Prostatitis. Part 4 by: admin

      December 2, 2009, 05:02

      Antimicrobial Regimens for the Treatment of Acute and Chronic Bacterial Prostatitis Drug class Dose* and Route Common Side Effects Comments T…

    • Diagnosis and Treatment of Prostatitis. Part 3 by: admin

      December 2, 2009, 05:00

      Chronic Bacterial Prostatitis Chronic bacterial prostatitis (CBP) occurs when acute bacterial prostatitis is treated inadequately due to resistance, relapse,…

    • Diagnosis and Treatment of Prostatitis. Part 2 by: admin

      December 1, 2009, 04:57

      Acute Bacterial Prostatitis Acute bacterial prostatitis (ABP) is the least common of the prostate infections. It is usually accompanied by a urinary tract…

    • Diagnosis and Treatment of Prostatitis. Part 1 by: admin

      November 30, 2009, 04:51

      Inflammation of the prostate gland may have bacterial or non-bacterial origins. Prostatitis is a broad term used to identify perianal and lower urinary…

    • Prostatitis Syndromes. Part 5: Treatment by: admin

      November 28, 2009, 07:48

      Experiments in animals show that most antimicrobial agents diffuse very poorly into the prostatic tissue and prostatic secretions. Experimentally, a notable…

    • Prostatitis Syndromes. Part 4: Diagnosis by: admin

      November 28, 2009, 07:47

      Cultures. In acute cases, documentation of a significant infection of the bladder urine is all that is required for definitive diagnosis. However, a urine…

    • Prostatitis Syndromes. Part 3: Diagnosis by: admin

      November 28, 2009, 07:46

      The history and physical examination can suggest the diagnosis, but most signs and symptoms of bacterial prostatitis, non-bacterial prostatitis, and even…

    • Prostatitis Syndromes. Part 2: Pathogenesis by: admin

      November 28, 2009, 07:45

      Bacterial. An understanding of the etiology and pathogenesis of prostatitis is essential in the investigation and treatment of these syndromes. The bacteria…

    • Prostatitis Syndromes. Part 1 by: admin

      November 28, 2009, 07:44

      The related syndromes of prostatitis remain a frustrating clinical entity both for clinicians, especially primary care physicians, and for their patients. The…

  • Category: Treatment  (13)
    • Case for Monotherapy by: admin

      June 21, 2011, 08:08

      TxNxMl: the Case for Monotherapy There has been a substantial increase in the incidence of prostate cancer recently, particularly in the proportion of…

    • Overview of Clinical Trials by: admin

      June 21, 2011, 08:07

      Twenty-seven randomized controlled trials involving 7987 patients compared the outcome of surgical or medical castration alone (monotherapy) to almost every…

    • Observations in Patient Subsets (Minimal Disease) by: admin

      June 21, 2011, 08:06

      Preliminary results of the INT-0036 trial suggested that the Combined androgen blockade effect could be more prominent in patients with minimal disease and…

    • Adverse Effects and Quality of Life by: admin

      June 21, 2011, 08:05

      Because hormonal treatment is primarily a palliative therapy and has not been shown to significantly affect survival in metastatic prostate cancer, it is…

    • Response to androgen blockade by: admin

      June 28, 2010, 08:59

      After the initiation of androgen deprivation therapy (ADT), most patients with prostate cancer will show some evidence of clinical response; the magnitude…

    • Mechanisms of androgen axis blockade by: admin

      June 25, 2010, 08:53

      There are four therapeutic approaches for androgen axis blockade in current clinical use: ablation of androgen sources, inhibition of androgen synthesis,…

    • Sources of androgen by: admin

      June 21, 2010, 08:27

      Testosterone is the major circulating androgen, with 90% produced by the testes. More than half of testosterone is bound to sex-binding globulin and 40% is…

    • General complications of androgen ablation by: admin

      June 15, 2010, 09:41

      Osteoporosis The increased number of men being prescribed androgen ablation therapy much earlier in the course of their disease allows the chronic manifestatio…

    • Liarozole: the Treatment of Recurrent Prostate Cancer by: admin

      January 30, 2010, 15:16

      Each year in the United States, 317,000 cases of prostate cancer are reported, with 41,400 men dying from it. About 50% of patients suffer from metastatic…

    • Herbal Help for Prostate Problems by: admin

      January 19, 2010, 03:59

      Saw palmetto berry extract helps to shrink swollen tissue, herbalists say When a 50-plus man starts to have trouble when he urinates, most doctors will have…

    • Chemotherapy: Drug-Resistance and Superinfection by: admin

      December 30, 2009, 15:59

      In the Individual Patient The use of two drugs in combination to delay the emergence of a drug-resistant strain is now a well established principle and is…

    • Chemotherapy: Bactericidal Synergy And Antagonism by: admin

      December 29, 2009, 15:51

      Jawetz & Gunnison (1953) in one of their now classic papers on 'Antibiotic Synergism and Antagonism' defined 'synergism' as 'the ability of two antimicrobia…

    • Chemotherapy: Introduction by: admin

      December 28, 2009, 15:48

      The use of antibiotic combinations for the treatment of bacterial infections has been the subject of many reviews (Garrod 1953, 1964, Chabbert 1953, Dowling…

  • Category: Book review  (7)
  • Category: Benign Prostatic Hyperplasia  (64)
  • Category: Drugs: Antibiotics  (2)
  • Category: Old Publications  (16)
  • Category: Images Diagrams Tables  (8)
  • Category: Pharmacotherapy  (3)
  • Category: Management  (9)
  • Category: Disorders  (5)
    • Prostatism: Surgery by: admin

      February 27, 2010, 01:37

      The indications for surgery in benign prostatic hypertrophy are essentially the symptoms confirmed by signs of prostatism. More absolute indications are those…

    • Prostatism: Urinary Retention by: admin

      February 25, 2010, 01:36

      Initial management of a patient in the prostatic age group presenting in urinary retention involves insertion of a urinary catheter. However, certain preventive…

    • Prostatism: Signs by: admin

      February 23, 2010, 01:35

      Having obtained the symptoms suggestive of outlet obstruction, the diagnosis should then be confirmed by the signs of outlet obstruction. On physical examinatio…

    • Prostatism: Symptoms by: admin

      February 21, 2010, 01:34

      The commonest symptom associated with prostatism is frequency and in particular, nocturia. The most objective of these is nocturia, since every patient…

    • Prostatism: Pathology by: admin

      February 19, 2010, 01:30

      Prostatism is the clinical syndrome consisting of the symptoms associated with outlet obstruction at the bladder neck. By far the commonest cause of this…

  • Category: Prostate Health  (1)
    • OTC Medications and Prostate Health by: admin

      March 17, 2010, 03:59

      The prostate is easily overlooked by the average male for about the first four decades of his life. It seldom causes overt symptoms during this time. However,…

  • Category: Drugs: α-blockers  (3)
  • Category: Dictionary  (6)
    • USA: Helpful organizations by: admin

      October 29, 2010, 16:53

      American Association for Cancer Education (AACE) A professional organization of educators in many disciplines who are working to improve the quality of…

    • Genes by: admin

      October 25, 2010, 17:21

      Some genes appear to increase a man's risk of developing many different types of cancer, including prostate cancer and testicular cancer. Prostate Cancer Gene…

    • Cryotherapy by: admin

      October 19, 2010, 17:19

      A minimally invasive and relatively new procedure used to treat localized prostate cancer that uses very low temperatures to "freeze" cancer cells. The…

    • Сomplementary and alternative medicine (CAM) by: admin

      October 15, 2010, 17:17

      A broad group of healing philosophies, approaches, and products (also referred to as integrative medicine) that are not presently considered to be part of…

    • MiniDictionary by: admin

      October 7, 2010, 16:34

      Prostate gland A structure about the shape of a walnut that wraps around the urethra, where it exits the base of a man's bladder. The prostate gland has three…

    • Prostate cancer by: admin

      October 3, 2010, 16:29

      Malignant tumors of the prostate gland. Prostate cancer is the most common non-skin form of cancer and the second-leading cause of deaths from cancer among…

  • Category: Hormonal Therapy  (11)
    • Secondary Hormonal Therapy by: admin

      June 21, 2011, 09:18

      Metastatic prostate cancer that progresses after initial androgen deprivation is most commonly referred to as hormone-refractory prostate cancer or androgen-ind…

    • Second-Line Antiandrogens by: admin

      June 21, 2011, 09:17

      The addition of flutamide at the time of progressive metastatic disease is associated with an objective response in 15% and disease stabilization in 20% of…

    • Inhibitors of P-450-Dependent Enzymes by: admin

      June 21, 2011, 09:16

      Ketoconazole is an antifungal agent that inhibits both sterol membrane synthesis and the cytochrome P-450-dependent enzyme 17,20-lyase (CYP34A). At high doses,…

    • Progesterones and Estrogens by: admin

      June 21, 2011, 09:15

      Megestrol acetate has several mechanisms of action that suggest a potential beneficial role in treating progressive metastatic prostate cancer. It inhibits the…

    • Is Early Hormonal Therapy Preferable? by: admin

      June 21, 2011, 08:15

      Widespread clinical use of prostate-specific antigen for the early detection and monitoring of treatment outcomes in prostate cancer has resulted in a…

    • Natural History of Metastatic Prostate Cancer by: admin

      June 21, 2011, 08:15

      Occult Metastases An important variable in "early hormonal" therapy is the definition of "early." Since the intent is to treat systemic disease effectively to…

    • Studies in Early Stage Disease by: admin

      June 21, 2011, 08:14

      The bulk of the experience on "early" hormonal therapy is derived from studies conducted by the Veterans Administration Cooperative Urological Research Group…

    • Studies in Metastatic Disease by: admin

      June 21, 2011, 08:13

      For half a century, systemic therapy of prostate cancer has centered on suppressing androgenic stimuli by either surgical or medical gonadal suppression. The…

    • Case for Hormonal Therapy by: admin

      June 21, 2011, 07:57

      T1b-T2NxM0: a Case for Hormonal Therapy? The role of androgen withdrawal therapy in hormone-naive, clinically localized prostate cancer has not been adequately…

    • Results of Hormonal Therapy for Localized Prostate Cancer by: admin

      June 21, 2011, 07:56

      Since the androgen dependence of prostate cancer was demonstrated by Huggins and Hodges, androgen withdrawal therapy has been used in treating advanced…

    • Quality-of-Life Issues: Intermittent Androgen Suppression by: admin

      June 21, 2011, 07:54

      The concept of intermittent androgen suppression was devised in an attempt to delay progression to the androgen-independent state by restoring apoptotic…

  • Category: Chemotherapy and Immunotherapy  (6)
    • Chemotherapy and Immunotherapy by: admin

      June 21, 2011, 09:30

      Management of Hormone-Refractory Prostate Cancer: Chemotherapy and immunotherapy The effective treatment of prostate cancer patients with advanced disease is…

    • Heterogeneity of Advanced Prostate Cancer by: admin

      June 21, 2011, 09:29

      In order to evaluate the potential impact of any therapy for prostate cancer, one must consider and attempt to define the heterogeneity present in the cohort…

    • Evaluation of Treatment Response by: admin

      June 21, 2011, 09:28

      Traditional Endpoints Clinical trials in oncology have traditionally used the end-points of tumor response and survival (median survival time) to determine…

    • Combination Chemotherapy by: admin

      June 21, 2011, 09:25

      With a few notable exceptions, reported combinations of cytotoxic chemotherapeutic agents have added little benefit to single-agent chemotherapy in the…

    • Immunotherapy by: admin

      June 21, 2011, 09:23

      Manipulation of the immune system to eradicate cancer is an attractive approach in that, in contrast to chemotherapeutic approaches, normal host cells are…

    • New Therapeutic Strategies and Future Directions by: admin

      June 21, 2011, 09:21

      Signal Transaction Modulators The binding of peptide growth factors such as transforming growth factor alpha (transforming growth factor-oc) and epidermal…

  • Category: Urological Oncology  (19)
    • Renal Cancer by: admin

      October 28, 2011, 15:09

      Renal cancer is a relatively rare cancer accounting for approximately 3% of all adult malignancies. There are more than 5000 new cases diagnosed per year in…

    • Principles of therapy by: admin

      October 28, 2011, 15:08

      Chemotherapy Cytotoxic chemotherapy remains the mainstay of systemic treatment for most solid cancers. Renal cell carcinoma however is a characteristic…

    • Drugs available by: admin

      October 28, 2011, 15:07

      Interferons Interferons are a heterogeneous group of glycoproteins produced by mammalian cells in response to viral infections or other inducers. Three major…

    • Future developments by: admin

      October 28, 2011, 15:04

      Anti-angiogenesis agents Angiogenesis refers to the formation of new blood vessels and is an important step in tumour growth. It is estimated that most…

    • Testicular Cancer by: admin

      October 28, 2011, 15:02

      A germ cell tumour of the testis is a rare disease although it is the most common tumour in men aged 20-35 years. The incidence of testicular cancer is about…

    • Non-seminoma stage I by: admin

      October 28, 2011, 15:01

      The cure rate for patients with non-seminomatous tumours in clinical stage I exceeds 95%. About 20% of patients with stage I disease without lymphatic or…

    • Non-seminoma stage II-Intravenous by: admin

      October 28, 2011, 14:59

      Disseminated non-seminoma is highly curable. In most patients, an orchiectomy  is   performed   before   starting  chemotherapy.   However,   if …

    • Treatment of recurrent disease by: admin

      October 28, 2011, 14:57

      Deciding on further treatment in case of recurrent testicular cancer depends on many factors, including the histology, prior treatment, site of recurrence, as…

    • Systemic Therapy for Bladder Cancer by: admin

      October 28, 2011, 14:53

      Despite radical treatments with curative intent, the chance of long-term survival for patients with muscle-invasive bladder cancer remains disappointing.…

    • Comparison of well-known combination regimens by: admin

      October 28, 2011, 14:51

      CMV and MVAC The CMV regimen  is a combination of cisplatin, methotrexate and, vinblastine. In the context of a randomized controlled phase III clinical…

    • Principles of therapy by: admin

      October 28, 2011, 14:48

      Selection of patients suitable to receive systemic chemotherapy Bladder cancer is a condition associated with smoking, the incidence of which rises…

    • Future developments by: admin

      October 28, 2011, 14:47

      Even with the latest developments in cytotoxic chemotherapy for bladder cancer, many patients die from muscle-invasive disease, despite aggressive therapy with…

    • Drugs in Superficial Bladder Cancer by: admin

      October 28, 2011, 14:44

      Since the introduction of thiotepa as an intravesical agent by Swinney et al. in 1961, drugs have been used in patients with superficial bladder cancer to try…

    • Intravesical chemotherapeutic agents by: admin

      October 28, 2011, 14:43

      Thiotepa (triethylene thiophosphoramide) Thiotepa was first used for intravesical therapy of superficial bladder cancer by Jones and Swinney. It is an…

    • Immunotherapy by: admin

      October 28, 2011, 14:41

      Bacille Calmette-Guerin Morales et al. first reported the benefits of intravesical Bacille Calmette-Guerin using six weekly installations of approximately 10…

    • Pharmacotherapy in the Management of Prostate Cancer by: admin

      October 28, 2011, 14:37

      Prostate cancer is now the second leading cause of death due to cancer in men. Prostate cancer is usually classified as being early/localized (organ confined),…

    • Management of localized prostate cancer by: admin

      October 28, 2011, 14:36

      Patients with clinically localized prostate cancer are generally offered either active surveillance or radical treatment, depending on their general condition…

    • Management of locally advanced prostate cancer by: admin

      October 28, 2011, 14:34

      Hormone therapy alone is generally employed for unfit patients with localized prostate cancer, a life expectancy of < 10 years and a Gleason score of >…

    • Hormone-relapsed prostate cancer by: admin

      October 28, 2011, 14:32

      Although many men with prostate cancer may be cured by radical treatment, many hundreds of thousands of men worldwide (40 000 in the USA alone) die annually…


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