Health and Prostate

Benign Prostatic Hyperplasia – Prostate Cancer – Prostatitis
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Posts Tagged ‘Doxycycline’

Antibiotics

Posted by admin on June 21st, 2011 No Comments
Most urologists will treat prostatitis empirically with a course of antibiotics prior to receiving the results of any bacteriologic studies that are performed. Furthermore, most would continue the antibiotic for a full course (2 to 12 weeks), irrespective of the culture results. The only change, typically, would be considered if the antibiogram indicated that a particular organism was resistant to the antibiotic employed. The time course for treatment is highly variable. Most authors and research indicate that a period of 30 days is adequate but literature exists to support as long as 3 to 6 months of therapy. A number of antibiotics have been touted as the most appropriate for the treatment of classic chronic bacterial prostatitis or category II; these drugs should be used in category IIIA as well. Carbenicillin indanyl sodium (Geocillin-Roche) was probably the first antibiotic to have a specific indication for the treatment of prostatitis. It has an excellent spectrum of activity but it is cumbersome for patients as it is dosed four times a day. The tetracyclines as a group have an appropriately Read more [...]
Posted in Prostatitis

Diagnosis and Treatment of Prostatitis. Part 5

Posted by admin on May 4th, 2011 No Comments
Nonbacterial Prostatitis Nonbacterial prostatitis (NBP) is the most common type of prostatitis, and occurs eight times more frequently than bacterial prostatitis. Nonbacterial prostatitis presents with the same signs and symptoms as bacterial prostatitis; however, prostatic fluid cultures are negative for presence of bacteria. Inflammation is evident upon prostatic fluid analysis, and can be identified by a minimum of 10 to 15 white blood cells per high power field on microscopic examination. Although controversial, implicated pathogens include Chlamydia trachomatis, Ureaplasma urealyticum, and Trichomonas vaginalis. Minocycline 100 mg twice daily, doxycycline 100 mg twice daily, or erythromycin 500 mg four times daily have been utilized in order to eradicate the suspected pathogens. Erythromycin’s antimicrobial activity is significantly enhanced in the presence of the alkaline pH in prostatic fluid, thus, it achieves high cure rates of prostatic infections. Treatment duration is approximately 2 to 4 weeks. Prolonged therapy after treatment failure is not indicated, since nonbacterial prostatitis Read more [...]
Posted in Prostatitis

MiniDictionary

Posted by admin on October 7th, 2010 No Comments
Prostate gland A structure about the shape of a walnut that wraps around the urethra, where it exits the base of a man's bladder. The prostate gland has three lobes and produces fluid that joins the semen (which the seminal glands produce), the viscous substance that transports sperm through the man's reproductive system and out of the body during ejaculation. For reasons researchers do not understand, the prostate gland gradually enlarges with age, a condition called benign prostatic hypertrophy (BPH). An enlarged prostate gland can compress the urethra, interfering with the flow of urine. Common health conditions affecting the prostate gland include prostatitis. The prostate gland also is a common site for cancer. Prostate cancer is more common after age 60, with an increasing risk with advancing age. A physician can palpate (explore through touch) the prostate gland through digital rectal examination (DRE). DRE can permit the detection of prostate enlargement and sometimes of growths or tumors. Prostatic massage Gentle pressure applied to the prostate gland to expel accumulations of fluid, Read more [...]
Posted in Dictionary

Diagnosis and Treatment of Prostatitis. Part 3

Posted by admin on December 2nd, 2009 No Comments
Chronic Bacterial Prostatitis Chronic bacterial prostatitis (CBP) occurs when acute bacterial prostatitis is treated inadequately due to resistance, relapse, short-course therapy or because the ductal anatomy of the peripheral zone of the prostate may have blocked drainage of secretions from the prostate. Rarely will some patients be found who have not had a previous bout of acute prostatitis. The most common clinical feature of chronic bacterial prostatitis is recurrent urinary tract infections. Subsequently, patients will complain of obstructive and irritative urinary symptoms. Physical exam reveals a palpable, tender prostate. However, patients often present asymptomatic, with a normal prostate gland exam. Localizing bacteria from the prostate is paramount in order to diagnose chronic bacterial prostatitis. The Stamy–Meares test is a collection of segmented urine samples from the urethra, bladder, and prostate; it is considered the gold standard for diagnosis. The patient voids and collects the first 5–10 mL of urinary stream (VB1), then collects a midstream specimen of 10–20 mL (VB2), Read more [...]
Posted in Prostatitis

Prostatitis Syndromes. Part 5: Treatment

Posted by admin on November 28th, 2009 No Comments
Experiments in animals show that most antimicrobial agents diffuse very poorly into the prostatic tissue and prostatic secretions. Experimentally, a notable exception was trimethoprim. Trimethoprim diffuses easily into prostatic secretion because of its favorable pharmacokinetics, which includes the pH of the prostatic fluid and tissue as well as the specific negative logarithm of the ionization constant of the drug. Trime-thoprim-sulphamethoxazole or trimethoprim alone have been the antimicrobial agents with the best documented record of success in treating chronic bacterial prostatitis. Theoretically, erythromycin and minocycline also achieve therapeutic levels in the secretions. However, these drugs are characterized by a high incidence of adverse side effects, and neither is really suitable for long-term use. The only antibiotic approved for chronic bacterial prostatitis is carbenicillin. Studies have not confirmed that this is the most appropriate drug for this disease. The new quinolones offer theoretical efficacy in that they do diffuse very freely into the prostatic secretion Read more [...]
Posted in Prostatitis

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