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Posts Tagged ‘Flomax’

Benign Prostatic Hyperplasia

Posted by admin on July 11th, 2011 No Comments

Definition Benign prostatic hyperplasia, a nearly ubiquitous condition, is the most common benign neoplasm of American men and occurs as a result of hormone-driven prostate growth. Pathophysiology The prostate gland comprises three types of tissue: epithelial or glandular, stromal or smooth muscle, and capsule. Both stromal tissue and capsule are embedded with О±1-adrenergic receptors. The precise pathophysiologic mechanisms that cause Benign prostatic hyperplasia are not clear. However, both intraprostatic dihydrotestosterone and type II 5 О±-reductase are thought to be involved. Benign prostatic hyperplasia commonly results from both static (gradual enlargement of the prostate) and dynamic (agents or situations that increase О±-adrenergic tone and constrict the gland's smooth muscle) factors. Examples of drugs that can exacerbate symptoms include testosterone, О±-adrenergic agonists (e.g., decongestants), anticholinergics (e.g., antihistamines, phenothiazines, tricyclic antidepressants, anticholinergic antispasmodics, Read more [...]

Posted in Benign Prostatic Hyperplasia

Alpha Blockers

Posted by admin on May 10th, 2011 No Comments

Overview Hyperplasia of the stromal tissue may or may not lead to significant enlargement of the prostate, but it usually leads to dynamic benign prostatic hyperplasia by increasing prostatic smooth muscle, which triggers increased smooth-muscle tension and resistance to urine flow. (The dynamic and static components of benign prostatic hyperplasia are discussed in the "Etiology and Pathophysiology" section.) Alpha1-adrenergic receptors in the bladder neck and prostatic capsule mediate tension in these muscles. Although the alpha1-adrenergic antagonists, or alpha blockers, currently used to block these receptors (e.g., doxazosin [Pfizer/AstraZeneca's Cardura/Cardura XL, generics] and terazosin [Abbott's Hytrin, generics]) reduce benign prostatic hyperplasia symptoms and resistance to urine flow, some of them also cause cardiovascular side effects. The latest entrants in this field (e.g., tamsulosin [Astel-las/Boehringer Ingelheim/Abbott's Harnal/Flomax/Omnic, others] and alfuzosin [Sanofi-Aventis's Xatral/Xatral SR/Uroxatral, others]) are prostate-specific or uroselective alpha blockers that reduce Read more [...]

Posted in Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia: Alpha Blockers

Posted by admin on May 10th, 2011 No Comments

Overview Numerous alpha blockers have been approved for the treatment of benign prostatic hyperplasia in the major pharmaceutical markets (United States, France, Germany, Italy, Spain, United Kingdom, and Japan), largely replacing the need for surgical treatment in the past ten years. Alpha blockers, with tamsulosin as the leading agent, currently constitute the largest segment of the benign prostatic hyperplasia drug market. Alpha-blocker drugs may differ in terms of their relative inhibitory potency and specificity for alpha1-adrenergic receptors, but most seem to exhibit the same degree of efficacy in benign prostatic hyperplasia patients . However, the propensity for inducing side effects, such as orthostatic hypotension and retrograde ejaculation, often distinguishes one alpha blocker from another. Nevertheless, alpha-blocker activity is sustained over several years of therapy, thereby eliminating the need for dose increases that could increase side effects. Mechanism Of Action Alpha blockers inhibit the activity of adrenergic receptors (also known as adrenoceptors), which cause smooth-muscle Read more [...]

Posted in Benign Prostatic Hyperplasia

Tamsulosin

Posted by admin on May 10th, 2011 No Comments

Tamsulosin (Astellas/Boehringer Ingelheim/Abbott's Harnal/Flomax/Omnic), the leading alpha blocker, is a long-acting alpha blocker that is selective for alpha1A- and alpha1A-adrenoceptors found predominantly in the prostate. Astellas (formerly Yamanouchi) initially marketed tamsulosin in an immediate-release formulation (Harnal) in Japan and Europe. Boehringer Ingelheim also markets tamsulosin in the United States as a delayed-release formulation (Flomax) to provide more consistent drug levels after each dose. In 1999, Abbott entered an agreement with Boehringer Ingelheim to comarket Flomax in the United States. Tamsulosin selectively binds to alpha1A- and alpha1D-adrenergic receptors, thereby blocking activation by norepinephrine. This highly selective drug reduces the incidence of adverse events because it does not affect alpha ib -adrenoceptors located in blood vessels, spleen, or lungs to a significant extent. Tamsulosin's efficacy is only marginally better than that of other alpha blockers, but it offers a superior side-effect profile. In a 13-week, parallel-design, double-blind Read more [...]

Posted in Benign Prostatic Hyperplasia

Benign Prostatic Hyperplasia:Current Therapies

Posted by admin on May 10th, 2011 No Comments

Treatment of benign prostatic hyperplasia (benign prostatic hyperplasia) is directed primarily toward managing symptoms and improving patients' quality of life (QoL). The two dominating classes of pharmacological agents used to treat benign prostatic hyperplasia are alpha Mockers and 5-alpha-reductase inhibitors (5-ARIs). Both drug classes are effective in alleviating lower urinary tract symptoms (lower urinary tract symptoms ) associated with benign prostatic hyperplasia, thereby improving patients' comfort level. Alpha blockers are most useful in alleviating symptoms related to dynamic benign prostatic hyperplasia; 5-ARIs are used for the treatment of static benign prostatic hyperplasia. The dynamic and static forms of benign prostatic hyperplasia are discussed in the "Etiology and Pathophysiology" section. Alpha blockers work by relaxing prostatic muscle involved in dynamic benign prostatic hyperplasia; they cannot stop further growth of the prostate. 5-ARIs and gonadotropin modulators (used only in Japan) reduce the cellular growth seen in static benign prostatic hyperplasia. lower Read more [...]

Posted in Benign Prostatic Hyperplasia

Tamsulosin Hydrochloride

Posted by admin on August 28th, 2010 No Comments

Drug Approvals (British Approved Name Modified, US Adopted Name, rINN) International Nonproprietary Names (INNs) in main languages (French, Latin, and Spanish): Synonyms: R-(-)-YM-12617; Amsulosin Hydrochloride; LY-253351; Tamsulosiinihydrokloridi; Tamsulosina, hidrocloruro de; Tamsulosinhydroklorid; Tamsulosini Hydrochloridum; YM-12617-1; YM-617 BAN: Tamsulosin Hydrochloride [BANM] USAN: Tamsulosin Hydrochloride INN: Tamsulosin Hydrochloride [rINNM (en)] INN: Hidrocloruro de tamsulosina [rINNM (es)] INN: Tamsulosine, Chlorhydrate de [rINNM (fr)] INN: Tamsulosini Hydrochloridum [rINNM (la)] INN: Тамсулозина Гидрохлорид [rINNM (ru)] Chemical name: (-)-(R)-5-(2-{[2-(o-Ethoxyphenoxy)ethyl]amino}-propyl)-2-methoxybenzenesulfonamide hydrochloride Molecular formula: C20H28N2O5S,HCl =445.0 CAS: 106133-20-4 (tamsulosin); 106463-17-6 (tamsulosin hydrochloride) ATC code: G04CA02 Read code: y09jI Pharmacopoeias. In Europe and Japan. European Pharmacopoeia, 6th ed. (Tamsulosin Hydrochloride). A white or almost white powder. Slightly soluble in water and anhydrous Read more [...]

Posted in Drugs

Management of benign prostatic hyperplasia (BPH)

Posted by admin on June 3rd, 2010 No Comments

The National Prescribing Centre (NPC) [UK] Summary Symptoms of benign prostatic hyperplasia (BPH) are common in older men. They result from hyperplasia of glandular tissue and increased smooth muscle tone. Many men accept these symptoms as a normal part of the ageing process, and do not seek treatment. As BPH is not always a progressive condition, and the incidence of complications is low, 'watchful waiting' is appropriate for men whose symptoms are mild. Men suffering severe symptoms, or who develop complications of benign prostatic hyperplasia such as acute urinary retention or recurrent urinary tract infection, should be referred to a urologist for consideration of surgical treatment. Transurethral resection of the prostate is the most commonly used surgical procedure. It is more effective than drug therapy, but is occasionally associated with complications such as impotence and incontinence. Alphaj-adrenoceptor blocking drugs reduce smooth muscle tone in the prostatic tissue and bladder neck, decreasing resistance to urinary flow. They can produce cardiovascular side-effects, such Read more [...]

Posted in Benign Prostatic Hyperplasia

TAMSULOSIN

Posted by admin on May 18th, 2010 No Comments

TAMSULOSIN (tam-SOO-loe-sin) Other Names for this Medication (Brand names): Flomax, Harnal, Omnic, Pradif, Tamsolusin, Tamsulosina [INN-Spanish], Tamsulosine [INN-French], Tamsulosinum [INN-Latin] Appearance Half orange-yellow and tan capsule marked with "FLOMAX 0.4 mg" on the orange side and "BI 58" on the tan side. Why this Medication is Used Tamsulosin is used in the treatment of benign prostatic hyperplasia or BPH (enlargement of the prostate gland) by relaxing muscles in the prostate and bladder, resulting in improved urine flow and reduced BPH symptoms. How do you take this Medication The usual dose is 0.4 mg once per day but this may be adjusted by your doctor to 0.8 mg per day depending on the patient and/or severity of the symptoms of BPH. Tamsulosin may be taken 30 minutes following the same meal every day. If you interrupt your treatment for several days or more, resume treatment at one capsule/day, after consulting your doctor. Precautions • Make sure to schedule regular check-ups with your doctor while taking tamsulosin. • Do not crush, chew or open capsules of tamsulosin, Read more [...]

Posted in Drugs

UroXatral: Drug for Treatment of BPH

Posted by admin on April 3rd, 2010 No Comments

Trade Name Drug: UroXatral Generic Name Drug: Alfuzosin HCl Company: Sanofi-Synthelabo Indication / Use: Benign prostatic hyperplasia Approval Date / FDA Class: 12 06 2003 / 1S Development and Mechanism of Action:Benign prostatic hyperplasia (BPH) is defined histologically. Clinically, it is characterized by lower urinary tract symptoms (urinary frequency, urgency, a weak and intermittent stream, needing to strain, a sense of incomplete emptying, and nocturia) and can lead to complications, including acute urinary retention. The mechanisms by which BPH causes symptoms and complications are unclear, although obstruction of the bladder outlet is an important factor. The best documented risk factors are increasing age and functioning testes. Estimates of the prevalence of symptomatic BPH indicate that approximately 50% of men ages 51 to 60 have benign prostatic hyperplasia. Community- and practice-based studies suggest that men with lower urinary tract symptoms can expect slow progression of the symptoms. However, symptoms can wax and wane without treatment. In men with symptoms of BPH, Read more [...]

Posted in Drugs: α-blockers

Selective and non-selective α-blockers for BPH: Application

Posted by admin on March 31st, 2010 No Comments

Application to clinical practice An important issue is extrapolation of the results of alfuzosin (Uroxatral) to the terazosin (Hytrin) we prescribe in Canada. Although the affinity αa/αb receptor ratio is similar for alfuzosin and terazosin, their incidence of association with signs of hypotension differ. In placebo-controlled trials, patients treated with terazosin experienced obvious signs of hypotension, whereas incidence among patients receiving tamsulosin (Flomax) and alfuzosin (Uroxatral) was similar to that among patients treated with placebo. This indirect comparison between α-blockers has, of course, important limitations but should be borne in mind when extrapolating results to terazosin (Hytrin). Two trials have directly compared tamsulosin (Flomax) with terazosin (Hytrin). One single-blind trial was conducted among Asian men with high-normal blood pressure levels and symptomatic benign prostatic hyperplasia (BPH). They received 0.2 mg of tamsulosin (half the dose white men would receive) or 5 mg of terazosin daily. Both groups experienced significant improvement in Qmax and symptom Read more [...]

Posted in Drugs: α-blockers

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