Benign Prostatic Hyperplasia – Prostate Cancer – Prostatitis

Posts Tagged ‘Nizoral’

Current Therapies

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The main treatment modalities for prostate cancer (CaP) include "watchful waiting"; local therapy (prostatectomy or radiotherapy, either external beam radiation therapy [EBRT] or brachytherapy); hormonal therapy; and chemotherapy. Watchful waiting is generally reserved for elderly men, who, because of short life expectancy or slowly progressing disease, are likely to die with CaP rather than because of CaP. Local therapies alone can often cure patients diagnosed with early-stage (I or II) prostate-confined disease. Hormonal therapy is used primarily to delay disease progression when local therapies have failed. Chemotherapy is generally reserved for hormone-refractory disease to palliate symptoms. A growing trend in CaP treatment is the use of intermittent therapy. Hormonal therapies are often administered for three years or more as adjuvant therapy. Although their sideeffect profile is mild compared with that of many chemotherapy agents, they do have several undesirable effects (e.g., hot flashes, sexual dysfunction, gynecomastia [excessive development of mammary glands]). To reduce these side Read more [...]

Pharmacotherapy for BPH (Benign Prostatic Hyperplasia)

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Mechanisms of Obstruction and Rationale for Pharmacotherapy Current pharmacotherapy for Benign Prostatic Hyperplasia (BPH) is based on agents that relax the smooth muscles of prostatic urethra and stroma and those that deprive acinar cells of androgen. Various agents have been tried in the treatment of BPH (Table). They may be broadly grouped into those affecting the dynamic component of urethral obstruction, namely the smooth muscle and prostatic stroma, and those affecting the glandular elements by androgen deprivation. The mechanism of action of many agents claimed to be useful in Benign Prostatic Hyperplasia is not clearly understood. TABLE — Drugs That Have Been Tried in the Medical Management of Benign Prostatic Hyperplasia (Some agents act by more than one mechanism) Drug Class Drug (Code Designation) Trade Name α1-Adrenergic antagonists Prazosin HCl Minipress Terazosin HCl Hytrin Doxazosin mesylate Cardura Phentolamine mesylate YM-617 Nicergoline Sermion Indoramin Baratol Ketanserin Yohimbine HCI Antiandrogens Selective 5α-Reductase Read more [...]

The role of ketoconazole in advanced prostate cancer

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Ketoconazole - Nizoral, Extina, Xolegel, Kuric Prostate cancer is the most common malignancy in American males above age 55. The cause of prostate cancer is not known. The most accepted risk factors are age, race and family history. Common signs and symptoms include dysuria, urethral obstruction, back or hip pain, and complications of advanced metastatic disease such as spinal cord compression and disseminated intravascular coagulation (DIC) syndrome. The American Urological System of staging prostate cancer designates four stages of tumor growth, A through D, with each stage containing substages. Stage A is occult, nonpalpable; stage B is palpable, macroscopic tumor; stage C is tumor with extracapsular extension, but still clinically localized; and stage D is metastatic disease. The management of prostate cancer is greatly influenced by the stage of the disease but also by the patient’s age, physical condition, and response to prior therapy. Traditionally, prostatectomy or radiation therapy is considered for patients with stage A or B disease and hormonal therapies that suppress the body’s Read more [...]