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Posts Tagged ‘Warfarin’

Angiogenesis Inhibitors

Posted by admin on May 6th, 2011 No Comments

Overview. Angiogenesis inhibition for the treatment of solid tumors has received a boost from the approval of bevacizumab (Genentech / Roche's Avastin) for the treatment of metastatic colorectal cancer. Angiogenesis inhibitors in development for CaP span a wide range of classes, including MAbs, selective metalloproteinase inhibitors, and thalidomide and its derivatives. Some agents discussed here have already demonstrated modest single-agent activity; current combination trials are designed to exploit synergies with chemotherapy. Some agents have also been investigated for maintenance use. The next sections describe the most promising of the many angiogenesis inhibitors in development—bevacizumab (Genentech / Roche's Avastin) and Celgene's thalidomide and CC-4047 (Actimid). One agent in Phase II development that may hold promise is squalamine (Genaera's MSI-1246), but the lack of published data precludes further discussion of it. Mechanism Of Action. Most anticancer angiogenesis inhibitors under development inhibit a single antiangiogenic pathway; the most promising pathway for inhibition Read more [...]

Posted in Prostate Cancer

Bicalutamide

Posted by admin on September 2nd, 2010 No Comments

(British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Bicalutamida; Bicalutamidum; Bikalutamid; Bikalutamidi; ICI-176334 BAN: Bicalutamide USAN: Bicalutamide INN: Bicalutamide [rINN (en)] INN: Bicalutamida [rINN (es)] INN: Bicalutamide [rINN (fr)] INN: Bicalutamidum [rINN (la)] INN: Бикалутамид [rINN (ru)] Chemical name: (RS)-4´-Cyano-α´,α´,α´-trifluoro-3-(4-fluorophenylsulphonyl)-2-hydroxy-2-methylpropiono-m-toluidide Molecular formula: C18H14F4N2O4S =430.4 CAS: 90357-06-5 ATC code: L02BB03 Read code: y088t Pharmacopoeias. In US. The United States Pharmacopeia 31, 2008 (Bicalutamide). A fine, white to off-white powder. Sparingly to slightly soluble in alcohol; freely soluble in acetone and in tetrahydrofuran; soluble in acetonitrile. Store in airtight containers. Adverse Effects and Precautions As for Flutamide. Pruritus, asthenia, alopecia, hair regrowth, and dry skin occur commonly with bicalutamide. Hyper sensitivity reactions, including Read more [...]

Posted in Drugs

Tamoxifen Citrate

Posted by admin on August 15th, 2010 No Comments

(British Approved Name Modified, US Adopted Name, rINNM) Drug Nomenclature INNs in main languages (French, Latin, Russian, and Spanish): Synonyms: ICI-46474; Tamoksifeenisitraatti; Tamoksifeno citratas; Tamoxifén-citrát; Tamoxifen citrát; Tamoxifencitrat; Tamoxifeni Citras; Tamoxifeno, citrato de BAN: Tamoxifen Citrate [BANM] USAN: Tamoxifen Citrate rINNM: Tamoxifen Citrate [rINNM (en)] INN: INN: Citrato de tamoxifeno [rINNM (es)] INN: Tamoxifène, Citrate de [rINNM (fr)] INN: Tamoxifeni Citras [rINNM (la)] INN: Тамоксифена Цитрат [rINNM (ru)] Chemical name: (Z)-2-[4-(1,2-Diphenylbut-1-enyl)phenoxy]ethyldimethylamine citrate Molecular formula: C26H29NO,C6H8O7 =563.6 CAS: 10540-29-1 (tamoxifen); 54965-24-1 (tamoxifen citrate) ATC code: L02BA01 Pharmacopoeias. In China, Europe, International, and US. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Tamoxifen Citrate). A white or almost white, polymorphic, crystalline powder. Slightly soluble in water and in acetone; soluble in methyl alcohol. The United States Pharmacopeia 31, 2008 Read more [...]

Posted in Drugs

Flutamide

Posted by admin on July 20th, 2010 No Comments

(British Approved Name, US Adopted Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Flutamid; Flutamida; Flutamidas; Flutamidi; Flutamidum; Sch-13521 BAN: Flutamide USAN: Flutamide INN: Flutamide [rINN (en)] INN: Flutamida [rINN (es)] INN: Flutamide [rINN (fr)] INN: Flutamidum [rINN (la)] INN: Флутамид [rINN (ru)] Chemical name: α´,α´,α´-Trifluoro-4´-nitroisobutyro-m-toluidide; α,α,α-Trifluoro-2-methyl-4´-nitro-m-propionotoluidide Molecular formula: C11H11F3N2O3 =276.2 CAS: 13311-84-7 ATC code: L02BB01 Read code: y02p1 Pharmacopoeias. In Europe and US. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Flutamide). A pale yellow, crystalline powder. Practically insoluble in water; freely soluble in alcohol and in acetone. Protect from light. The United States Pharmacopeia 31, 2008 (Flutamide). A pale yellow, crystalline powder. Practically insoluble in water, in liquid paraffin, and in petroleum spirit; freely soluble in acetone, in ethyl acetate, Read more [...]

Posted in Drugs

Aminoglutethimide

Posted by admin on July 20th, 2010 No Comments

(British Approved Name, rINN) Drug Nomenclature International Nonproprietary Names (INNs) in main languages (French, Latin, Russian, and Spanish): Synonyms: Aminoglutethimid; Aminoglutethimidum; Aminoglutetimid; Aminoglutetimida; Aminoglutetimidas; Aminoglutetimidi; Ba-16038 BAN: Aminoglutethimide INN: Aminoglutethimide [rINN (en)] INN: Aminoglutetimida [rINN (es)] INN: Aminoglutéthimide [rINN (fr)] INN: Aminoglutethimidum [rINN (la)] INN: Аминоглутетимид [rINN (ru)] Chemical name: 2-(4-Aminophenyl)-2-ethylglutarimide; 3-(4-Aminophenyl)-3-ethylpiperidine-2,6-dione Molecular formula: C13H16N2O2 =232.3 CAS: 125-84-8 ATC code: L02BG01 Read code: y02oN Pharmacopoeias. In China, Europe, and US. European Pharmacopoeia, 6th ed., 2008 and Supplements 6.1 and 6.2 (Aminoglutethimide). A white or slightly yellow, crystalline powder. Practically insoluble in water; freely soluble in acetone; soluble in methyl alcohol. The United States Pharmacopeia 31, 2008 (Aminoglutethimide). A white or creamy-white, fine, crystalline powder. Very slightly soluble in water; readily Read more [...]

Posted in Drugs

TAMSULOSIN

Posted by admin on May 18th, 2010 No Comments

TAMSULOSIN (tam-SOO-loe-sin) Other Names for this Medication (Brand names): Flomax, Harnal, Omnic, Pradif, Tamsolusin, Tamsulosina [INN-Spanish], Tamsulosine [INN-French], Tamsulosinum [INN-Latin] Appearance Half orange-yellow and tan capsule marked with "FLOMAX 0.4 mg" on the orange side and "BI 58" on the tan side. Why this Medication is Used Tamsulosin is used in the treatment of benign prostatic hyperplasia or BPH (enlargement of the prostate gland) by relaxing muscles in the prostate and bladder, resulting in improved urine flow and reduced BPH symptoms. How do you take this Medication The usual dose is 0.4 mg once per day but this may be adjusted by your doctor to 0.8 mg per day depending on the patient and/or severity of the symptoms of BPH. Tamsulosin may be taken 30 minutes following the same meal every day. If you interrupt your treatment for several days or more, resume treatment at one capsule/day, after consulting your doctor. Precautions • Make sure to schedule regular check-ups with your doctor while taking tamsulosin. • Do not crush, chew or open capsules of tamsulosin, Read more [...]

Posted in Drugs

FLUTAMIDE

Posted by admin on May 6th, 2010 No Comments

FLUTAMIDE (FLUTE-am-eyed) Other Names for this Medication: Euflex®, Drogenil®, Eulexin ®, Apo-flutamide®, Novo-flutamide®, Pms-flutamide® (Brand Names) Appearance Oral Tablets: Round, pale yellow, tablet containing 250 mg of flutamide. Why this Medication is Used This medication may be used alone, or in combination with other medications for the treatment of prostate cancer. Flutamide blocks the male hormone that stimulates the growth of prostate cancer cells. How do you take this Medication Oral Tablets: Take this drug by mouth, with or without food, as ordered by your doctor. Precautions • Other medications may interact with Flutamide. Do not start taking new medications without first checking with your doctor or pharmacist. Tell your doctor if you are taking blood-thinning drugs such as Coumadin® (Warfarin). • Tell all other doctors or dentists that you are taking Flutamide, before you receive treatment from them. • Store Flutamide tablets at room temperature. Keep out of the reach of children. For more information on this medication, please call your doctor, Read more [...]

Posted in Drugs

BICALUTAMIDE

Posted by admin on April 24th, 2010 No Comments

BICALUTAMIDE (bye-cal-LOO-ta-mide) Other Names for this Medication Casodex, Cosudex, Calutide, Kalumid (Brand Names) Appearance White tablet containing 50 mg Bicalutamide Why this Medication is Used This medication may be used alone, or in combination with other medications for the treatment of prostate cancer. Bicalutamide blocks the male hormone that stimulates the growth of prostate cancer cells. How do you take this Medication The tablet is taken with a full glass of water usually once a day, with or without food. It may be taken in the morning or the evening, but should be taken at the same time each day. Precautions • Other medications may interact with Bicalutamide. It is important to tell your doctor if you are taking any other medications (even over-the-counter ones and herbal products and supplements). Do not start or stop taking any medications without first checking with your doctor and pharmacist. • Tell your doctor if you are taking the blood-thinning drug, Coumadin® (Warfarin). Your doctor will need to closely monitor your blood clotting time and adjust your drug Read more [...]

Posted in Drugs

ALFUZOSIN

Posted by admin on April 20th, 2010 No Comments

ALFUZOSIN (al-FOO-zoe-sin) Other Names for this Medication: US - Uroxatral, Canada - Xatral Appearance White and yellow 3 layered round (10 mg) tablets Why this Medication is Used Alfuzosin is used in the treatment of benign prostatic hyperplasia or BPH (enlargement of the prostate gland) by relaxing muscles in the prostate and bladder, resulting in improved urine flow and reduced BPH symptoms. How do you take this Medication The usual dose is 1 0mg once per day. Alfuzosin may be taken 30 minutes after the same meal every day. Do not take Alfuzosin tablets on an empty stomach. If you interrupt your treatment for several days or more, resume treatment at one tablet daily, after consulting your doctor. Avoid drinking grapefruit juice and eating grapefruits while being treated with Alfuzosin. Precautions • Make sure to schedule regular check-ups with your doctor while taking Alfuzosin. • Do not crush or chew tablets of Alfuzosin, as the tablets are specially made to regulate the release of Alfuzosin into the blood stream. Swallow the tablets whole. • Avoid driving or operating Read more [...]

Posted in Drugs

Drug Interactions in the Treatment of ED, LUTS and BPH: Clinically Relevant Drug-Drug Interactions

Posted by admin on December 27th, 2009 No Comments

Clinically Relevant Drug-Drug Interactions With the 5-Alpha-Reductase Inhibitors Neither dutasteride nor finasteride have any clinically significant pharmacodynamic or pharmacokinetic adverse drug interactions. Studies show that the 5-alpha-reductase inhibitors do not affect the CYP 450 enzyme system. However, agents that inhibit the CYP 450 3A4 may, in theory, interfere with metabolism of these medications. Therefore, until more data are available, cautious monitoring should follow the concurrent administration of a 5-alpha-reductase inhibitor with an agent known to alter the activity of the hepatic mixed function oxidase enzyme system. Pharmacodynamic Drug-Drug Interactions With PDE-5 Inhibitors Pharmacodynamic drug interactions leading to precipitous hypotension and MI are clinically relevant with PDE-5 inhibitors. All selective inhibitors of cyclic GMP-specific PDE-5 are prone to clinically significant pharmacodynamic interactions with agents that produce vasodilation. The concurrent use of nitrate preparations is a contraindication to treatment with selective inhibitors of cyclic GMP-specific Read more [...]

Posted in Benign Prostatic Hyperplasia

Posts Tagged ‘Warfarin’

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